TrkB Antibody / NTRK2 / Neurotrophic receptor tyrosine kinase 2, 100ug

Tropomyosin Receptor Kinase B antibody, also known as NTRK2 antibody, recognizes a receptor tyrosine kinase commonly referred to as TrkB and brain-derived neurotrophic factor receptor. The NTRK2 gene encodes a high-affinity transmembrane receptor for neurotrophins including BDNF and neurotrophin-4, playing a pivotal role in neuronal survival, synaptic plasticity, axonal growth, and differentiation. TrkB is highly expressed in the central nervous system, particularly in cortical neurons, hippocampal pyramidal cells, and cerebellar granule neurons, where it regulates long-term potentiation and memory-associated signaling pathways.<br><br>Tropomyosin Receptor Kinase B contains an extracellular ligand-binding domain composed of leucine-rich motifs and immunoglobulin-like regions, a single-pass transmembrane segment, and an intracellular tyrosine kinase domain responsible for downstream signaling. Upon ligand engagement, TrkB undergoes dimerization and autophosphorylation at specific tyrosine residues, activating MAPK-ERK, PI3K-AKT, and PLC-gamma pathways. These cascades promote neuronal survival, metabolic adaptation, and resistance to apoptosis. NTRK2 antibody detection is valuable for studying receptor activation dynamics and neurotrophin-mediated signaling mechanisms.<br><br>Alternative splicing of NTRK2 generates both full-length kinase-active isoforms and truncated variants lacking the intracellular catalytic domain. These truncated forms can modulate ligand availability and receptor trafficking, influencing cellular responsiveness to neurotrophins. Expression patterns vary across tissue types, and TrkB has also been detected in certain epithelial and endocrine tissues. Aberrant NTRK2 signaling has been implicated in tumor progression, invasion, and therapeutic resistance in selected malignancies, making reliable detection important in oncology research.<br><br>Subcellular localization of TrkB includes the plasma membrane and intracellular vesicular compartments associated with receptor internalization and signaling endosomes. Interaction with adaptor proteins such as SHC1 and GRB2 integrates NTRK2 into broader growth factor signaling networks. Clone NTRK2/7925 is designed for research applications involving detection of Tropomyosin Receptor Kinase B expression in formalin-fixed, paraffin-embedded tissues and other laboratory assays. A Tropomyosin Receptor Kinase B antibody supports investigation of neurodevelopment, neurodegenerative disease, and oncogenic NTRK2 alterations.

Specifications