P Glycoprotein Antibody / MDR1 / ABCB1, 20ug

MDR1 antibody, also known as Multidrug resistance protein 1 antibody, recognizes a transmembrane ATP-dependent drug efflux transporter encoded by the ABCB1 gene. Multidrug resistance protein 1, commonly referred to as P-glycoprotein and CD243, is a member of the ATP-binding cassette transporter superfamily. The protein is predominantly localized to the plasma membrane, particularly at the apical surface of polarized epithelial cells. High expression is observed in intestine, liver canalicular membranes, kidney proximal tubules, placental trophoblasts, and endothelial cells of the blood-brain barrier, where it contributes to xenobiotic protection and pharmacologic barrier function.<br><br>Multidrug resistance protein 1 functions as an ATP-driven efflux pump that transports a wide range of structurally diverse substrates out of cells. By reducing intracellular drug accumulation, MDR1 plays a central role in chemotherapeutic resistance across multiple cancer types. MDR1 antibody, also referred to as ABCB1 antibody and P-glycoprotein antibody in the literature, is widely used to study mechanisms of drug resistance, epithelial transport biology, and pharmacokinetic regulation.<br><br>Structurally, Multidrug resistance protein 1 contains two transmembrane domains that create the substrate translocation pathway and two cytoplasmic nucleotide-binding domains responsible for ATP binding and hydrolysis. Conformational changes induced by ATP hydrolysis drive substrate extrusion across the plasma membrane. The protein undergoes glycosylation and other post-translational modifications that regulate stability and membrane targeting. In polarized tissues, MDR1 is enriched at the apical membrane, facilitating directional transport into luminal spaces.<br><br>Overexpression of MDR1 is frequently associated with acquired drug resistance in breast, ovarian, colorectal, and hematologic malignancies. Elevated expression correlates with decreased responsiveness to chemotherapy and altered therapeutic outcomes. Beyond oncology, ABCB1 influences systemic drug distribution and central nervous system penetration. Clone ABCB1/9307 recognizes Multidrug resistance protein 1 and is suitable for detecting MDR1 expression in relevant research applications.

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