P Glycoprotein Antibody / MDR1 / ABCB1, 20ug

CD243 antibody, also known as Multidrug Resistance 1 antibody, recognizes a plasma membrane-associated ATP-dependent efflux transporter encoded by the ABCB1 gene. CD243 is the cluster of differentiation designation for the protein commonly referred to as P-glycoprotein and Multidrug Resistance 1. It belongs to the ATP-binding cassette transporter superfamily and is predominantly localized to the apical membrane of polarized epithelial cells. Physiologic expression is observed in intestine, liver canalicular membranes, kidney proximal tubules, placental trophoblasts, and endothelial cells of the blood-brain barrier, where it functions as a protective xenobiotic export pump.<br><br>Multidrug Resistance 1 actively transports a wide range of structurally unrelated compounds out of cells using energy derived from ATP hydrolysis. By reducing intracellular accumulation of cytotoxic agents, CD243 plays a central role in the development of chemotherapeutic resistance in multiple malignancies. CD243 antibody is frequently used in oncology research to evaluate drug resistance phenotypes, tumor efflux capacity, and therapeutic response prediction. In hematologic and flow cytometry contexts, CD243 is recognized as a cell surface marker associated with drug-resistant populations.<br><br>Structurally, Multidrug Resistance 1 contains two transmembrane domains that create the substrate translocation pathway and two cytoplasmic nucleotide-binding domains responsible for ATP binding and hydrolysis. ATP-driven conformational changes enable substrate extrusion across the membrane. The protein is glycosylated and undergoes post-translational processing that influences membrane targeting and stability. In polarized tissues, CD243 is enriched at the luminal surface, supporting directional efflux into bile, urine, or intestinal lumen.<br><br>Overexpression of CD243 has been documented in breast, ovarian, colorectal, and hematologic cancers following exposure to chemotherapeutic agents. Elevated expression is associated with decreased intracellular drug retention and reduced treatment efficacy. Beyond oncology, Multidrug Resistance 1 contributes to pharmacokinetics, blood-brain barrier integrity, and toxin clearance. Clone ABCB1/9309 recognizes CD243 and is suitable for detecting Multidrug Resistance 1 expression in relevant research applications.

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