SERPINB5 Antibody / MASPIN, 100ug

Serpin B5 antibody, also known as Mammary Protease Inhibitor antibody, recognizes a cytoplasmic and nuclear protein encoded by the SERPINB5 gene on chromosome 18q21.33. Serpin B5, historically referred to as Mammary Serine Protease Inhibitor and commonly known as Maspin, is a member of the clade B serpin family. Unlike classical inhibitory serpins, Serpin B5 does not function as a conventional serine protease inhibitor. Instead, it regulates epithelial cell differentiation, adhesion, migration, and apoptosis. Expression is primarily observed in epithelial tissues including breast, prostate, lung, and skin, where it contributes to epithelial integrity and tissue homeostasis.<br><br>Serpin B5 has been widely studied as a tumor suppressor protein in breast and other epithelial cancers. Reduced or lost expression has been associated with increased tumor invasiveness and metastatic potential in certain carcinoma models. Mammary Protease Inhibitor antibody is frequently used in oncology research to evaluate epithelial differentiation status and to assess subcellular localization patterns that may correlate with tumor behavior. Both cytoplasmic and nuclear staining patterns have been reported, and differential localization has been investigated in relation to prognosis in specific tumor types.<br><br>Structurally, Serpin B5 belongs to the ovalbumin-like subgroup of serpins but lacks the canonical reactive center loop required for irreversible protease inhibition. Instead, it interacts with components of the extracellular matrix and intracellular signaling molecules, influencing integrin signaling, cell-matrix adhesion, and apoptotic pathways. Epigenetic regulation, including promoter methylation, has been described as a mechanism contributing to reduced SERPINB5 expression in aggressive malignancies.<br><br>In normal tissues, Serpin B5 expression is typically restricted to epithelial compartments, making it a useful marker for epithelial lineage studies. Clone SERPINB5/12555 recognizes Serpin B5 and is suitable for detecting Mammary Protease Inhibitor expression in relevant research applications.

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