SERPINB5 Antibody / MASPIN, 20ug

Mammary Serine Protease Inhibitor antibody, also known as MASPIN antibody, recognizes Serpin family B member 5, a cytoplasmic and nuclear protein encoded by the SERPINB5 gene on chromosome 18q21.33. Mammary Serine Protease Inhibitor, commonly referred to as MASPIN, belongs to the clade B serpin family but does not function as a classical serine protease inhibitor. Instead, it acts as a regulatory protein involved in epithelial differentiation, adhesion, and tumor suppression. Expression is primarily observed in epithelial tissues such as breast, prostate, lung, and skin, where it contributes to maintenance of epithelial architecture.<br><br>MASPIN has been extensively studied for its tumor suppressor properties. Decreased or absent expression has been associated with increased tumor invasion and metastatic potential in several carcinoma types, including breast and prostate cancers. Mammary Serine Protease Inhibitor antibody is widely used in oncology research to evaluate epithelial lineage, tumor differentiation, and subcellular localization patterns. Both cytoplasmic and nuclear staining patterns have been described, and altered localization has been investigated in relation to tumor behavior and prognosis.<br><br>At the structural level, MASPIN shares the conserved serpin fold but lacks critical residues necessary for irreversible protease inhibition. Instead, SERPINB5 interacts with extracellular matrix components and intracellular signaling pathways that regulate cell motility, apoptosis, and integrin signaling. Epigenetic silencing through promoter methylation has been reported as a mechanism for reduced MASPIN expression in aggressive malignancies.<br><br>In normal tissues, Mammary Serine Protease Inhibitor is predominantly restricted to epithelial compartments, supporting its use as an epithelial marker in research applications. Clone SERPINB5/12556 recognizes MASPIN and is suitable for detecting SERPINB5 expression in relevant research studies.

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