SERPINB5 Antibody / MASPIN, 100ug

PI5 antibody, also known as Peptidase inhibitor 5 antibody, recognizes a member of the serine protease inhibitor family commonly referred to as Maspin and encoded by the SERPINB5 gene. Peptidase Inhibitor 5 belongs to the clade B serpin family and functions primarily as a non-secreted, cytoplasmic and nuclear serine protease inhibitor with tumor suppressive properties. It is highly expressed in epithelial tissues including skin, mammary gland, prostate, and other stratified epithelia, where it contributes to regulation of cell adhesion, migration, apoptosis, and differentiation.<br><br>Peptidase Inhibitor 5, also referred to as Mammary serine protease inhibitor and Serpin B5 in the literature, plays a role in maintaining normal epithelial architecture. In healthy tissues, expression is typically observed in basal and suprabasal epithelial layers, while altered expression patterns have been reported in multiple tumor types. Loss or mislocalization of SERPINB5 has been associated with tumor progression, invasion, and metastasis in breast, prostate, lung, and colorectal cancers. Conversely, preserved nuclear localization is often correlated with more differentiated phenotypes.<br><br>At the molecular level, SERPINB5 participates in pathways regulating extracellular matrix interaction, cell motility, and apoptosis. It has been reported to influence integrin signaling, modulate urokinase-type plasminogen activator activity, and interact with histone deacetylase complexes in the nucleus. These diverse functions support its classification as a multifunctional tumor suppressor protein rather than a simple protease inhibitor. The protein lacks a classical secretion signal and is predominantly localized to the cytoplasm and nucleus depending on cell type and context.<br><br>Chromosomally, SERPINB5 is located on 18q21.33 within a cluster of clade B serpin genes. Structurally, it contains the conserved serpin fold with beta sheets and alpha helices characteristic of inhibitory serpins, although its inhibitory mechanism differs from classical circulating serpins such as Alpha 1 Antitrypsin. Tissue distribution studies demonstrate strong epithelial staining in skin, mammary ducts, prostate epithelium, and other glandular tissues. A PI5 antibody is suitable for detecting SERPINB5 expression in research applications including immunohistochemistry, immunoblotting, and related assays for epithelial biology and oncology research.<br><br>Clone SERPINB5/12558 is a monoclonal antibody designed to target Peptidase Inhibitor 5 for research applications. It enables evaluation of epithelial differentiation status, tumor suppressor expression, and alterations in subcellular localization patterns associated with disease states.

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