PTGS2 Antibody / Prostaglandin-endoperoxide synthase 2, 100ug

PTGS2 antibody recognizes Prostaglandin-Endoperoxide Synthase 2, the inducible isoform of cyclooxygenase encoded by the human PTGS2 gene. Prostaglandin-Endoperoxide Synthase 2 is a key rate-limiting enzyme in prostaglandin biosynthesis and is commonly referred to in the literature as COX-2. Unlike the constitutively expressed PTGS1 isoform, PTGS2 expression is tightly regulated and rapidly induced by inflammatory cytokines, growth factors, tumor promoters, and cellular stress. The protein localizes predominantly to the endoplasmic reticulum and nuclear envelope, where it converts arachidonic acid into prostaglandin H2, a precursor for multiple bioactive lipid mediators.<br><br>Functionally, PTGS2 plays a central role in inflammation, pain signaling, fever response, and tissue remodeling. It participates in pathways downstream of NF-kappaB, MAPK, and other pro-inflammatory signaling cascades. Elevated PTGS2 expression is observed in activated macrophages, endothelial cells, fibroblasts, and epithelial cells exposed to inflammatory stimuli. In normal tissues, expression is typically low or absent, but strong upregulation occurs during acute and chronic inflammatory processes.<br><br>PTGS2 has significant relevance in oncology. Overexpression has been documented in colorectal carcinoma, breast cancer, lung cancer, prostate cancer, and renal cell carcinoma, where it contributes to tumor cell proliferation, resistance to apoptosis, angiogenesis, and immune modulation. Increased PTGS2 activity enhances prostaglandin E2 production, which promotes tumor-associated inflammation and supports a protumorigenic microenvironment. These roles have made PTGS2 both a widely studied biomarker and a therapeutic target of nonsteroidal anti-inflammatory drugs and selective COX-2 inhibitors.<br><br>The PTGS2 antibody clone r4H12 is a recombinant monoclonal antibody designed to target PTGS2 in research applications. Recombinant production in mammalian expression systems promotes lot-to-lot consistency and defined specificity. This PTGS2 antibody is suitable for detecting Prostaglandin-Endoperoxide Synthase 2 expression in tissue sections and lysates where inducible cyclooxygenase activity is of interest, particularly in studies of inflammation, tumor biology, and vascular remodeling.

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