PVALB Antibody / Parvalbumin, 100ug

Calcium-Binding Protein PV antibody, also known as PVALB antibody, recognizes Parvalbumin, a small cytosolic EF-hand calcium-binding protein encoded by the human PVALB gene on chromosome 22q12.3. Commonly referred to as Parvalbumin or PV in the literature, this protein is predominantly localized in the cytoplasm and is highly expressed in fast-twitch skeletal muscle fibers and in specific subsets of inhibitory GABAergic interneurons within the cerebral cortex, hippocampus, and cerebellum. Calcium-Binding Protein PV antibody is widely used to identify fast-spiking interneurons that play a central role in regulating cortical excitability and network synchronization.<br><br>Parvalbumin functions as a high-affinity intracellular calcium buffer. Structurally, it contains three EF-hand motifs, two of which are functional calcium-binding domains that rapidly bind calcium following membrane depolarization. This buffering activity accelerates muscle relaxation in fast-contracting fibers and shapes the timing and precision of inhibitory synaptic transmission in neurons. In the developing brain, Parvalbumin expression increases during postnatal maturation of interneurons, coinciding with the refinement of inhibitory circuitry and establishment of gamma oscillations.<br><br>In skeletal muscle biology, Parvalbumin levels correlate with glycolytic fast-twitch fiber identity and metabolic specialization. In the central nervous system, Parvalbumin-positive interneurons often co-localize with synaptic proteins involved in vesicle docking and release, reflecting their specialization for rapid, high-frequency firing. Altered expression or dysfunction of Parvalbumin-expressing interneurons has been associated with neurological and psychiatric disorders including epilepsy, schizophrenia, and autism spectrum disorders, where disrupted inhibitory signaling contributes to abnormal cortical dynamics.<br><br>Calcium-Binding Protein PV antibody is suitable for detecting Parvalbumin expression in studies of neural circuitry, muscle physiology, and disease-related alterations in calcium homeostasis. Recombinant monoclonal clone PVALB/12794R is produced using defined expression systems to promote consistent performance and supply reliability. A PVALB antibody such as clone PVALB/12794R supports research focused on calcium-buffering proteins and fast-spiking neuronal populations.

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