CXCR5 Antibody / BLR1, 20ug

CXCR5 Chemokine Receptor antibody, also known as CD185 antibody, recognizes C-X-C motif chemokine receptor 5, a seven-transmembrane G protein-coupled receptor encoded by the CXCR5 gene and commonly referred to as Burkitt lymphoma receptor 1 and BLR1. CXCR5 Chemokine Receptor is primarily localized to the plasma membrane of B lymphocytes and subsets of T cells, particularly follicular helper T cells, where it mediates chemokine-driven migration. As a member of the CXC chemokine receptor family, CXCR5 binds the chemokine CXCL13 and plays a central role in lymphoid follicle organization and germinal center formation.<br><br>CXCR5 Chemokine Receptor antibody detects a multi-pass transmembrane receptor composed of seven alpha-helical membrane-spanning domains, extracellular regions responsible for ligand binding, and intracellular domains that couple to heterotrimeric G proteins. Upon engagement with CXCL13, CXCR5 activates signaling pathways that promote cytoskeletal rearrangement and directed chemotaxis. Through these mechanisms, CD185 directs B cells and T follicular helper cells into B cell follicles within secondary lymphoid tissues, supporting antibody affinity maturation and adaptive immune responses.<br><br>Functionally, CXCR5 is essential for proper germinal center architecture and humoral immunity. Expression of CD185 defines follicular B cells and T follicular helper cells and is widely used as a marker in immunophenotyping and lymphoid tissue studies. Dysregulated CXCR5 signaling has been implicated in autoimmune diseases, chronic inflammatory conditions, and lymphoid malignancies. In certain B cell lymphomas, altered CXCR5 expression may influence tumor cell localization and interactions within the lymphoid microenvironment.<br><br>The CXCR5 gene is located on chromosome 11 and is transcriptionally regulated during lymphocyte activation and differentiation. Because CXCR5 Chemokine Receptor expression is largely restricted to defined immune cell subsets, detection of this receptor provides insight into lymphocyte trafficking, germinal center dynamics, and immune cell compartmentalization in normal and disease contexts.<br><br>The CXCR5 Chemokine Receptor antibody (clone CXCR5/13098) is suitable for detecting CD185 protein expression in research applications. This CD185 antibody supports investigation of B cell biology, T follicular helper cell function, lymphoid tissue organization, and immune-mediated disease mechanisms.

Specifications