UPK2 Antibody / Uroplakin 2, 20ug

UPK2 antibody recognizes Uroplakin 2, a transmembrane protein encoded by the human UPK2 gene and a critical structural component of the urothelial plaque. Uroplakin 2 is specifically expressed in the umbrella cells of the urothelium lining the urinary bladder, ureters, and renal pelvis. As a differentiation marker of urothelial cells, UPK2 antibody is widely used in research focused on urothelial biology and bladder carcinoma characterization.<br><br>Uroplakin 2 belongs to the uroplakin family, which includes UPK1A, UPK1B, UPK2, and UPK3A. These proteins assemble into heterodimeric complexes that form highly organized crystalline plaques on the apical surface of urothelial umbrella cells. Uroplakin 2 pairs with Uroplakin 1A to form a heterodimer that is subsequently incorporated into larger hexagonal arrays. These plaques create a permeability barrier that protects underlying tissues from urine toxicity and mechanical stress. Detection of Uroplakin 2 therefore reflects terminal urothelial differentiation and apical membrane specialization.<br><br>UPK2 is localized to the apical plasma membrane of superficial umbrella cells, where it contributes to plaque rigidity and barrier integrity. Expression is largely restricted to urothelial tissue, making Uroplakin 2 a highly specific marker for cells of urothelial origin. In pathologic settings, UPK2 expression is maintained in many urothelial carcinomas, including invasive bladder carcinoma, and can assist in distinguishing urothelial tumors from other carcinomas in metastatic contexts.<br><br>The UPK2 gene is located on chromosome 11q23 and encodes a glycosylated membrane protein that undergoes processing and assembly within the endoplasmic reticulum prior to trafficking to the apical membrane. UPK2 antibody clone UPK2/13669R is a recombinant rabbit monoclonal antibody developed to detect Uroplakin 2 in research applications, supporting studies of urothelial differentiation and tumor origin assessment.

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