UPK2 Antibody / Uroplakin 2, 100ug

Uroplakin 2 antibody recognizes Uroplakin 2, a urothelial differentiation protein encoded by the human UPK2 gene and a key structural component of the urothelial plaque. Uroplakin 2, also referred to as UPK2, is selectively expressed in the superficial umbrella cells of the urothelium lining the urinary bladder, ureters, and renal pelvis. Because of its restricted tissue distribution, Uroplakin 2 antibody is widely used in research investigating urothelial biology and bladder carcinoma.<br><br>Uroplakin 2 is a member of the uroplakin family, which includes UPK1A, UPK1B, UPK2, and UPK3A. These proteins assemble into heterodimeric complexes that form highly ordered crystalline plaques on the apical surface of umbrella cells. Uroplakin 2 pairs specifically with Uroplakin 1A, forming a heterodimer that is incorporated into larger hexagonal arrays within the asymmetric unit membrane. These plaques provide structural rigidity and create a permeability barrier that protects underlying tissues from urine toxicity and mechanical stress. Detection of Uroplakin 2 therefore reflects terminal urothelial differentiation and specialized apical membrane architecture.<br><br>UPK2 is localized predominantly to the apical plasma membrane of differentiated umbrella cells, where it contributes to barrier integrity and bladder surface stability. Expression is largely confined to urothelial tissue, making Uroplakin 2 a highly specific marker of urothelial origin. In pathologic settings, UPK2 expression is retained in many urothelial carcinomas, including invasive bladder carcinoma and metastatic urothelial tumors, supporting its utility in studies of tumor lineage and differentiation status.<br><br>The UPK2 gene is located on chromosome 11q23 and encodes a glycosylated membrane protein that undergoes post-translational processing and assembly within the endoplasmic reticulum before trafficking to the apical surface. Uroplakin 2 antibody clone UPK2/13348R is a recombinant rabbit monoclonal antibody developed to detect UPK2 in research applications, supporting studies of urothelial differentiation and bladder tumor characterization.

Specifications