Calbindin Antibody / CALB1, 100ug

D28K antibody, also known as CALB1 antibody, recognizes D28K, a widely used abbreviated name for the calcium-binding protein Calbindin 1 encoded by the CALB1 gene. The D28K designation reflects the approximate 28 kDa molecular size of this EF-hand calcium-binding protein and is commonly used in western blot figures, neuronal marker studies, and calcium signaling research. D28K functions as an intracellular calcium buffer that modulates the amplitude and kinetics of calcium transients, thereby shaping downstream signaling responses in excitable and secretory cells.<br><br>D28K is a member of the calbindin subfamily within the larger EF-hand protein family and contains six EF-hand motifs, four of which are capable of binding Ca2+ with high affinity. By reversibly binding calcium ions, D28K influences intracellular diffusion of calcium and limits cytotoxic calcium overload. This buffering activity is particularly important in cells exposed to rapid calcium flux, such as neurons and endocrine cells. Altered expression of CALB1 has been associated with dysregulated calcium homeostasis in neurodegenerative disorders, where reduced D28K levels may contribute to increased cellular susceptibility to stress and excitotoxic injury.<br><br>In the nervous system, D28K expression is frequently examined in the context of neuronal circuit mapping, interneuron characterization, and studies of synaptic plasticity. Outside the brain, CALB1 expression is detected in kidney distal tubular epithelium, intestinal absorptive cells, and pancreatic islets, where it supports calcium transport and hormone secretion processes. Because D28K is often cited in abbreviated form in primary research articles and figure legends, D28K antibody provides a convenient and literature-consistent terminology for investigators working with calcium-binding protein pathways. Clone rCALB1/9805 is a recombinant mouse monoclonal antibody generated through defined sequence expression, supporting lot-to-lot consistency and reproducibility in research applications focused on calcium regulation and cell type identification.

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