ABCC3 Antibody / ATP-binding cassette subfamily C member 3, 20ug

ABCC3 antibody recognizes ATP-binding cassette subfamily C member 3, a membrane efflux transporter encoded by the ABCC3 gene and commonly referred to as MRP3. Also known as Multidrug resistance-associated protein 3, this ATP-dependent transporter is a member of the ABC transporter superfamily and plays an important role in the export of organic anions and drug conjugates. ABCC3 antibody is widely used in research focused on hepatobiliary transport, xenobiotic metabolism, and mechanisms of multidrug resistance in cancer.<br><br>MRP3 is a multi-pass transmembrane protein localized primarily to the basolateral membrane of hepatocytes and epithelial cells in tissues such as intestine, pancreas, and kidney. The protein contains two nucleotide-binding domains and multiple transmembrane segments characteristic of ABC transporters. ABCC3 functions as an ATP-driven efflux pump transporting glucuronide, sulfate, and glutathione conjugates, including bile acids and bilirubin metabolites, from cells into systemic circulation. In cholestatic conditions or when canalicular transport pathways are impaired, ABCC3 expression is often upregulated as a compensatory mechanism to facilitate basolateral export of conjugated substrates.<br><br>Altered expression of MRP3 has been reported in inflammatory liver disease, cholestasis, and various malignancies. Increased ABCC3 levels have been associated with resistance to certain chemotherapeutic agents due to enhanced drug efflux capacity. Immunostaining typically demonstrates membranous localization in epithelial tumor cells and hepatocytes, consistent with plasma membrane transporter function. Clone rDTX1 is a recombinant mouse monoclonal antibody generated through defined sequence expression, supporting reproducible performance and lot-to-lot consistency. This ABCC3 antibody enables investigation of transporter biology, drug resistance pathways, and hepatic detoxification processes in research applications.

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