CD19 Antibody / CD19 molecule, 20ug

CD19 Molecule antibody recognizes CD19, a B cell-specific type I transmembrane glycoprotein that functions as a central coreceptor in B cell receptor signaling. CD19 Molecule Antibody (Clone CD19/4260R) is engineered to detect CD19 with high specificity in research applications requiring consistent performance. CD19 is a member of the immunoglobulin superfamily and is expressed from early pro-B cell stages through mature peripheral B lymphocytes, where it localizes to the plasma membrane. By forming a signaling complex with CD21 and CD81, CD19 amplifies antigen receptor-mediated signaling and lowers the activation threshold of B cells.<br><br>The CD19 gene is located on chromosome 16p11.2 and encodes a protein containing two extracellular immunoglobulin-like domains, a single transmembrane region, and a cytoplasmic tail enriched in tyrosine residues that become phosphorylated following activation. These phosphorylation events recruit signaling molecules such as PI3K and adaptor proteins, driving downstream pathways that regulate B cell proliferation, differentiation, and survival. CD19 Molecule Antibody | Clone CD19/4260R supports investigations into normal B cell development as well as dysregulated signaling associated with immune disorders and hematologic malignancies.<br><br>In normal human tissues, CD19 expression is restricted to B lineage cells within bone marrow, lymph node, tonsil, and spleen. Terminally differentiated plasma cells typically exhibit reduced or absent CD19 expression, reflecting late-stage B cell maturation. Because of its lineage specificity and stable membrane localization, CD19 serves as a reliable pan-B cell marker in immunologic and translational research settings.<br><br>Aberrant CD19 expression is characteristic of most B cell malignancies, including B cell acute lymphoblastic leukemia, chronic lymphocytic leukemia, and multiple forms of non-Hodgkin lymphoma. CD19 has also emerged as a major therapeutic target in immunotherapy strategies such as chimeric antigen receptor T cell approaches. Accurate detection of CD19 is therefore critical for studies of tumor biology, immune targeting, and therapeutic development.<br><br>Clone CD19/4260R is a recombinant rabbit monoclonal antibody designed to provide defined sequence identity and lot-to-lot reproducibility. Recombinant expression supports consistent binding characteristics and reliable detection of membrane-associated CD19 in research applications. CD19 Molecule Antibody (Clone CD19/4260R) provides strong membranous staining in CD19-positive B cells with minimal background in non-B cell populations.

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