CD19 Antibody / B lymphocyte antigen CD19, 100ug

CD19 antibody recognizes CD19, a B lymphocyte surface glycoprotein that functions as a critical coreceptor in B cell receptor signaling. B lymphocyte antigen CD19 Antibody (Clone CD19/13031R) is designed for specific detection of CD19 in research applications focused on B cell biology and lymphoid malignancies. CD19 is a member of the immunoglobulin superfamily and is expressed from early pro-B cell stages through mature peripheral B lymphocytes, where it localizes to the plasma membrane. By forming a signaling complex with CD21 and CD81, CD19 amplifies antigen receptor-mediated signaling and lowers the activation threshold of B cells.<br><br>The CD19 gene is located on chromosome 16p11.2 and encodes a type I transmembrane protein containing two extracellular immunoglobulin-like domains, a single transmembrane region, and a cytoplasmic tail enriched in tyrosine residues that become phosphorylated upon B cell activation. These phosphorylation events recruit signaling molecules such as PI3K and adaptor proteins, driving downstream pathways that regulate B cell proliferation, differentiation, and survival. B lymphocyte antigen CD19 Antibody (Clone CD19/13031R) supports investigations into normal B cell development and dysregulated signaling associated with immune disorders and hematologic malignancies.<br><br>In normal human tissues, CD19 expression is restricted to B lineage cells within bone marrow, lymph node, tonsil, and spleen. Terminally differentiated plasma cells typically exhibit reduced or absent CD19 expression, reflecting late-stage B cell maturation. Because of its lineage specificity and stable membrane expression, CD19 serves as a reliable pan-B cell marker in immunologic and translational research settings.<br><br>Aberrant CD19 expression characterizes most B cell malignancies, including B cell acute lymphoblastic leukemia, chronic lymphocytic leukemia, and various non-Hodgkin lymphomas. CD19 has also become a major therapeutic target in immunotherapy strategies such as chimeric antigen receptor T cell approaches. Accurate detection of CD19 is therefore essential for studies of tumor biology, immune targeting, and therapeutic development.<br><br>Clone CD19/13031R is a recombinant rabbit monoclonal antibody engineered for defined sequence identity and consistent lot-to-lot performance. Recombinant production supports reliable binding characteristics and strong membranous staining of CD19-positive B cells with minimal background in non-B cell populations. B lymphocyte antigen CD19 Antibody (Clone CD19/13031R) provides dependable performance for researchers investigating B cell distribution, immune regulation, and B cell-driven disease processes.

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