CD20 Antibody / Membrane spanning 4-domains A1, 20ug

MS4A1 antibody recognizes Membrane spanning 4-domains subfamily A member 1, commonly known as CD20, a B-cell specific transmembrane phosphoprotein encoded by the MS4A1 gene. CD20 is localized to the plasma membrane of B lymphocytes, where it regulates B-cell activation, proliferation, and calcium signaling. MS4A1 Antibody / Membrane spanning 4-domains A1 is developed to support research in B-cell biology, lymphoma investigation, and immune cell profiling.<br><br>The MS4A1 gene is located on chromosome 11q12.2 and encodes a protein characterized by four transmembrane domains with short cytoplasmic N- and C-terminal regions. CD20 expression begins at the late pre-B-cell stage and persists through mature B cells but is absent on hematopoietic stem cells and terminally differentiated plasma cells. This restricted lineage expression makes CD20 one of the most widely used markers for identifying B-cell populations in lymphoid tissues such as tonsil, spleen, lymph node, and bone marrow.<br><br>Functionally, CD20 associates with the B-cell receptor signaling complex and contributes to calcium influx following antigen engagement. Although CD20 lacks a defined soluble ligand, it participates in membrane microdomains that regulate signal transduction and B-cell activation. Aberrant CD20 expression is characteristic of B-cell non-Hodgkin lymphoma, diffuse large B-cell lymphoma, follicular lymphoma, and chronic lymphocytic leukemia. MS4A1 antibody supports evaluation of CD20 distribution and density in both normal and malignant B-cell populations.<br><br>Clone L26 and clone IGEL/773 are mouse monoclonal antibodies developed to recognize epitopes on CD20 suitable for detection in research applications. CD20 remains a major therapeutic target in oncology and autoimmune disease, and assessment of CD20 expression is important in translational studies examining treatment response and antigen modulation.<br><br>By targeting a well-established B-cell lineage marker, MS4A1 Antibody / Membrane spanning 4-domains A1 provides a dependable tool for studies of lymphoma classification, immune regulation, and B-cell differentiation.

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