MUC16 Antibody / CA125, 20ug

Cancer antigen 125 Antibody recognizes Mucin 16 (MUC16), a very high molecular weight transmembrane glycoprotein widely known as CA125 and Ovarian cancer antigen 125. MUC16 is a membrane-associated mucin characterized by extensive O-linked glycosylation, multiple tandem repeat domains, and a large extracellular region that can be proteolytically shed into circulation. Cancer antigen 125 Antibody is useful for detecting MUC16 expression in epithelial and tumor tissues in research applications.<br><br>MUC16 antibody, also referred to as CA125 antibody and Mucin-16 antibody in the literature, targets a mucin primarily expressed on the apical surface of epithelial cells lining the female reproductive tract, including endometrium and fallopian tube, as well as in ocular and respiratory epithelium. Under physiologic conditions, MUC16 contributes to epithelial barrier protection, lubrication, and defense against environmental stress. Release of its extracellular domain forms circulating CA125, which serves as a widely used serum biomarker for monitoring ovarian carcinoma.<br><br>The MUC16 gene is located on human chromosome 19p13.2 and encodes one of the largest membrane-associated proteins identified. Structurally, the protein contains numerous SEA domains, extensive tandem repeats, a transmembrane region, and a short cytoplasmic tail that participates in intracellular signaling interactions. MUC16 has been shown to bind mesothelin and contribute to tumor cell adhesion and peritoneal dissemination in ovarian cancer models.<br><br>Aberrant overexpression of MUC16 is most strongly associated with epithelial ovarian carcinoma and is also observed in subsets of endometrial, pancreatic, breast, lung, and gastrointestinal carcinomas. In histologic sections, MUC16 typically demonstrates apical membranous and cytoplasmic staining in positive epithelial tumor cells. A CA125 antibody is commonly applied in research settings to evaluate epithelial differentiation, tumor origin, and mucin biology. Clone CA125/8893 is a mouse monoclonal antibody developed to target MUC16 in experimental systems.

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