TNFSF15 Antibody / Tumor necrosis factor ligand superfamily member 15, 100ug

DR3 Ligand antibody recognizes Tumor necrosis factor ligand superfamily member 15, also known as TNFSF15, VEGI, and TL1A, a cytokine that functions as the cognate ligand for Death Receptor 3, encoded by the TNFRSF25 gene. As the TNFRSF25 ligand, this protein plays a central role in immune regulation and inflammatory signaling. DR3 Ligand Antibody is developed to detect endogenous TNFSF15 in research applications focused on receptor-ligand biology and T cell activation pathways.<br><br>TNFRSF25, commonly referred to as DR3, is a member of the tumor necrosis factor receptor superfamily expressed on T lymphocytes and other immune cell populations. Binding of its ligand triggers downstream signaling cascades involving NF-kappaB activation and apoptosis-related pathways. Through this interaction, the TNFRSF25 ligand regulates T helper cell expansion, cytokine production, and adaptive immune responses. Dysregulated signaling in this pathway has been implicated in autoimmune disease, chronic inflammation, and immune-mediated tissue injury.<br><br>The gene encoding DR3 Ligand, TNFSF15, is located on chromosome 9q32 and produces a type II transmembrane protein that can be proteolytically cleaved to generate a soluble cytokine form. Expression has been documented in endothelial cells, antigen-presenting cells, and inflamed tissues. In addition to immune activation, the protein historically described as Vascular endothelial growth inhibitor exhibits anti-angiogenic properties, linking receptor-mediated immune signaling with vascular remodeling processes.<br><br>Altered TNFSF15 expression has been associated with inflammatory bowel disease, rheumatoid arthritis, and tumor-associated immune modulation. In oncologic contexts, VEGI has been investigated for its ability to influence tumor angiogenesis and immune microenvironment dynamics. These dual immune and vascular functions make DR3 Ligand a critical mediator at the interface of inflammation and endothelial biology.<br><br>Clone VEGI/13117 is a monoclonal antibody that recognizes the TNFRSF25 ligand and supports studies of DR3-mediated signaling, cytokine regulation, and immune pathway modulation in diverse experimental systems.<br><br>For additional TL1A / TNFSF15 / VEGI research antibodies targeting inflammatory cytokine signaling and TNF superfamily immune pathways, explore the broader <a href=../tds/recombinant-tl1a-antibody-tnfsf15-vegi-rvegi1283-v3637>TL1A Antibody</a> page featuring recombinant rabbit monoclonal clone rVEGI/1283.

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