Cytomegalovirus Antibody / UL83 / CMV matrix protein pp65, 100ug

Phosphoprotein 65 antibody recognizes UL83, also known as pp65, Human cytomegalovirus phosphoprotein 65, and Major Tegument Protein, a highly abundant structural component of Human cytomegalovirus virions. Phosphoprotein 65 Antibody targets one of the most immunodominant viral proteins expressed during active HCMV infection and packaged within the viral tegument layer. As the UL83 gene product, pp65 serves as both a structural virion protein and a regulator of host immune responses.<br><br>The UL83 gene encodes a lower matrix phosphoprotein that localizes primarily to the cytoplasm of infected cells, with early nuclear trafficking observed shortly after viral entry. As a tegument-associated protein, pp65 is delivered into host cells during infection and participates in modulation of innate immune signaling pathways, including interference with interferon-mediated antiviral responses. This activity contributes to viral immune evasion and supports efficient viral replication.<br><br>Phosphoprotein 65 is abundantly expressed during lytic infection and is widely used as a biomarker for active cytomegalovirus replication in research applications. Because of its strong immunogenicity, pp65 is a dominant antigen recognized by cytotoxic T lymphocytes in infected individuals. Its high expression levels and structural role in virion assembly make UL83 a preferred target for detection of HCMV-infected cells in experimental systems studying viral pathogenesis and host-virus interactions.<br><br>The UL83 protein is conserved across clinical HCMV isolates and remains central to investigations of transplant-associated CMV reactivation, congenital infection, and viral persistence in immunocompromised populations. Detection of pp65 expression assists in characterizing infection dynamics and evaluating antiviral strategies in laboratory models.<br><br>Clone rCMV/12688 is a recombinant mouse monoclonal antibody that recognizes UL83 / Phosphoprotein 65 and supports research applications focused on cytomegalovirus detection, viral replication studies, and immune response characterization.

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