Periostin Antibody / POSTN, 20ug

POSTN antibody recognizes Periostin, a secreted extracellular matrix protein encoded by the POSTN gene and also known as osteoblast specific factor 2. POSTN Antibody for IHC (clone MSVA-649M) is a mouse monoclonal antibody developed for immunohistochemical detection of this matricellular protein in formalin-fixed, paraffin-embedded tissues. Periostin is synthesized with a signal peptide and secreted into the extracellular space, where it integrates into the interstitial matrix and basement membrane to regulate tissue architecture and cell-matrix signaling.<br><br>POSTN antibody, also referred to as Periostin antibody and OSF-2 antibody in the literature, targets a member of the fasciclin family characterized by an N-terminal EMI domain and four tandem fasciclin-like domains. These domains enable interaction with integrins such as alpha v beta 3 and alpha v beta 5, as well as extracellular matrix components including collagen type I and fibronectin. Through these interactions, Periostin supports fibroblast activation, cytoskeletal organization, and collagen fibrillogenesis, particularly in tissues subjected to mechanical stress and remodeling.<br><br>POSTN expression is enriched in periosteum, periodontal ligament, heart valves, placenta, and fibrous connective tissues. During development and wound repair, Periostin is upregulated to promote extracellular matrix deposition and structural stabilization. In cardiovascular biology, it contributes to valvular morphogenesis and adaptive remodeling. Increased Periostin expression is also associated with fibrotic conditions, where persistent matrix production contributes to tissue stiffening and organ dysfunction.<br><br>In oncology research, Periostin is frequently detected within tumor-associated stroma rather than malignant epithelial cells. Elevated POSTN expression has been reported in breast, lung, colorectal, pancreatic, and ovarian cancers, where it is commonly localized to cancer-associated fibroblasts and peritumoral connective tissue. This stromal distribution pattern makes POSTN antibody for IHC valuable for investigating tumor microenvironment biology, epithelial-mesenchymal interactions, and stromal activation in tissue-based analyses.<br><br>The mouse monoclonal clone MSVA-649M enables specific visualization of Periostin expression patterns in normal and diseased tissues for research use at NSJ Bioreagents.<br><br>This antibody is also part of a broader collection of <a href='/ihc-antibodies-tissue-microarray-validated.html'>IHC antibodies validated by tissue microarray analysis</a>, supporting consistent staining across normal and cancer tissues.

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