COL4A1 Antibody / Collagen type IV alpha 1 chain, 100ug

COL4A1 Antibody for IHC detects Collagen type IV alpha 1 chain, a major structural component of basement membranes encoded by the COL4A1 gene. This recombinant monoclonal antibody is designed for immunohistochemistry applications and enables evaluation of basement membrane integrity and extracellular matrix architecture in formalin-fixed tissue sections.<br><br>COL4A1 antibody, also referred to as Collagen IV antibody and Type IV collagen antibody in the literature, recognizes the alpha 1 chain that participates in formation of the Collagen IV heterotrimeric network. Collagen type IV alpha 1 associates with alpha 2 chains to form the predominant alpha 1 alpha 1 alpha 2 protomer found in most basement membranes. Unlike fibrillar collagens, Collagen IV forms a sheet-like scaffold that provides mechanical stability and structural compartmentalization between epithelial, endothelial, and stromal compartments. These networks interact with laminins, nidogens, and heparan sulfate proteoglycans to regulate cell adhesion, differentiation, migration, and barrier function.<br><br>COL4A1 is widely expressed in vascular basement membranes, kidney glomeruli, lung alveoli, skeletal muscle endomysium, and epithelial basement membrane zones across many organs. In immunohistochemical analyses, Collagen type IV alpha 1 typically demonstrates linear brown staining outlining blood vessels, glandular structures, and epithelial-stromal interfaces. This characteristic basement membrane pattern supports studies of angiogenesis, tumor invasion, and extracellular matrix remodeling in both developmental and disease contexts.<br><br>Pathogenic variants in COL4A1 have been linked to small vessel disease, cerebral hemorrhage susceptibility, ocular defects, and renal abnormalities. In cancer research, discontinuity or loss of Collagen IV staining may indicate basement membrane disruption and invasive potential. A COL4A1 Antibody for IHC can therefore assist in investigations of vascular pathology, basement membrane biology, and tissue microenvironment changes. This antibody targets Collagen type IV alpha 1 in research applications and is available from NSJ Bioreagents.<br><br>This antibody is also part of a broader collection of <a href='/ihc-antibodies-tissue-microarray-validated.html'>IHC antibodies validated by tissue microarray analysis</a>, supporting consistent staining across normal and cancer tissues.

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