SATB2 Antibody / Transcription factor SATB2, 100ug

SATB2 Antibody for IHC recognizes Transcription factor SATB2, also known as Special AT-rich sequence-binding protein 2, encoded by the SATB2 gene on chromosome 2q33.1. SATB2 is a nuclear matrix-associated transcription factor that functions as a chromatin organizer, binding AT-rich DNA elements and coordinating higher-order chromatin architecture with gene expression. The protein contains two CUT domains and a homeodomain that enable sequence-specific DNA binding and recruitment of transcriptional regulatory complexes. SATB2 localizes predominantly to the nucleus, where it exhibits a granular or reticular staining pattern reflecting its role in chromatin remodeling and transcriptional control.<br><br>SATB2 plays a central role in embryonic development, particularly in cortical neuron differentiation, craniofacial patterning, and osteoblast lineage commitment. In the developing cerebral cortex, SATB2 regulates projection neuron identity and connectivity by controlling transcriptional networks essential for neuronal specification. In skeletal tissues, it supports osteogenic differentiation and bone formation by modulating genes involved in extracellular matrix production and mineralization. In adult tissues, SATB2 expression is most prominent in glandular epithelial cells of the lower gastrointestinal tract, especially colorectal mucosa, where it contributes to maintenance of regional epithelial identity and differentiation.<br><br>In research and pathology-focused investigations, SATB2 is widely studied as a nuclear marker of colorectal epithelial origin. Strong nuclear expression is frequently observed in colorectal adenocarcinomas, supporting its use in studies evaluating tumor differentiation and lineage. SATB2 expression has also been reported in osteogenic tumors and select lower gastrointestinal neoplasms, reflecting its developmental and tissue-specific functions.<br><br>Clone MSVA-702R is a rabbit monoclonal antibody designed for immunohistochemical detection of SATB2 in formalin-fixed, paraffin-embedded tissues. Epitope-specific recognition supports clear nuclear staining with minimal background in optimized conditions. SATB2 Antibody for IHC (MSVA-702R) is suitable for detecting nuclear SATB2 expression in research applications focused on colorectal biology, neuronal development, skeletal differentiation, and chromatin organization.<br><br>This antibody is also part of a broader collection of <a href='/ihc-antibodies-tissue-microarray-validated.html'>IHC antibodies validated by tissue microarray analysis</a>, supporting consistent staining across normal and cancer tissues.<br><br>Researchers investigating colorectal tumor markers, epithelial lineage determination, and chromatin-associated transcriptional regulation may also be interested in our <a href=../tds/recombinant-satb2-antibody-satb24374r-v8660>SATB2 Antibody / Colorectal and Lineage Marker</a> page featuring validated immunohistochemistry and western blot applications for colorectal pathology research.

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