CELA3B Antibody / Chymotrypsin like elastase 3B, 100ug

CELA3B Antibody for IHC recognizes Chymotrypsin-like elastase family member 3B, a secreted digestive serine protease commonly referred to as pancreatic elastase 3B or elastase 3B. The human CELA3B gene is located on chromosome 1p36.12 and encodes a protein that is highly expressed in pancreatic acinar cells, where it is synthesized, processed, and stored within zymogen granules prior to secretion into the duodenum. As a member of the chymotrypsin family of serine proteases, CELA3B plays an important role in dietary protein digestion through regulated proteolytic activity in the intestinal lumen.<br><br>Chymotrypsin-like elastase family member 3B belongs to the elastase subfamily of trypsin-like proteases and shares strong structural homology with CELA3A. The enzyme is produced as a preproprotein containing a signal peptide that directs entry into the secretory pathway, followed by an activation peptide that maintains the protease in an inactive state until cleavage by trypsin. The mature enzyme adopts the conserved serine protease fold with a catalytic triad that mediates peptide bond hydrolysis. Because of its secretory routing, CELA3B localizes to the endoplasmic reticulum and Golgi during biosynthesis and is concentrated within cytoplasmic secretory granules of pancreatic acinar cells prior to extracellular release.<br><br>CELA3B is sometimes referenced in clinical literature under the term fecal elastase 1, reflecting its stability in stool and its use as a biochemical marker of pancreatic exocrine function. In tissue-based research settings, elastase 3B is widely recognized as a lineage-associated marker of acinar differentiation. Immunohistochemical studies have demonstrated strong expression in normal pancreatic acinar cells, while comparative tumor profiling supports its relevance in the evaluation of pancreatic acinar cell carcinoma and other exocrine pancreatic neoplasms. These characteristics make CELA3B a useful target in research panels focused on pancreatic development, differentiation, and tumor classification.<br><br>Genetic investigations have also linked CELA3B variants to inherited or familial pancreatitis phenotypes, underscoring its biological importance in digestive enzyme regulation and pancreatic homeostasis. Dysregulation of digestive protease activation is a central mechanism in pancreatitis pathogenesis, and CELA3B contributes to the tightly controlled proteolytic environment of the exocrine pancreas. The recombinant mouse monoclonal clone MSVA-410M is designed to detect CELA3B expression in formalin-fixed, paraffin-embedded tissue samples, supporting research applications centered on pancreatic acinar biology and elastase family protein expression.<br><br>This antibody is also part of a broader collection of <a href='/ihc-antibodies-tissue-microarray-validated.html'>IHC antibodies validated by tissue microarray analysis</a>, supporting consistent staining across normal and cancer tissues.<br><br>Researchers studying pancreatic differentiation, exocrine digestive enzyme biology, and acinar cell-associated tumor pathways may also be interested in our <a href=../tds/elastase-3b-antibody-cela3b-cela3b1257-v3436>Elastase 3B Antibody / Pancreatic Digestive Enzyme</a> page featuring validated immunohistochemistry and western blot applications for pancreatic research.

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