CD4 Antibody / CD4 molecule, 100ug

CD4 molecule (CD4) is a cell surface glycoprotein expressed primarily on T helper lymphocytes, with additional expression on subsets of monocytes, macrophages, and dendritic cells, where it functions as a co-receptor for antigen recognition through interaction with major histocompatibility complex class II molecules. CD4 Antibody for IHC is specifically used in immunohistochemistry to detect CD4-positive immune cells within formalin-fixed paraffin-embedded (FFPE) tissue sections, enabling visualization of lymphocyte distribution within intact tissue architecture.<br><br>CD4 antibody, also known as T helper cell marker antibody or CD4 surface receptor antibody, is a central tool for immunohistochemistry-based evaluation of immune cell localization. CD4 Antibody for IHC allows identification of CD4-positive T helper lymphocytes within tissue compartments, including lymphoid structures, epithelial-associated immune infiltrates, and stromal regions. In FFPE tissues, this staining provides critical spatial context, allowing researchers and pathologists to assess how CD4-positive cells are organized within normal tissues and sites of inflammation.<br><br>This CD4 Antibody for IHC (clone MSVA-004R) has been extensively evaluated using human tissue microarrays (TMA), enabling systematic analysis of CD4-positive cell distribution across a wide range of normal and cancer tissues under standardized staining conditions. TMA-based immunohistochemistry is particularly valuable for comparing staining patterns across multiple tissue types in a single experiment, and CD4 Antibody for IHC demonstrates staining patterns that align with expected immune localization, including strong enrichment of CD4-positive lymphocytes in lymphoid tissues such as tonsil and spleen, as well as variable presence in peripheral organs.<br><br>In the context of tumor biology, CD4 Antibody for IHC is highly informative for evaluating the immune microenvironment. Immunohistochemistry staining reveals CD4-positive T helper cells within tumor stroma, at invasive tumor margins, and in some cases within tumor cell nests, reflecting the complexity of tumor-immune interactions. TMA analysis highlights significant variability in CD4-positive cell density across different tumor types, including lymphomas and carcinomas, supporting comparative assessment of immune infiltration patterns. CD4 Antibody for IHC is therefore widely used in studies examining tumor-associated lymphocytes and immune response within the tumor microenvironment.<br><br>CD4 is localized to the plasma membrane of immune cells, and in immunohistochemistry, CD4 Antibody for IHC produces a predominantly membranous staining pattern that enables clear visualization of individual lymphocytes within tissue sections. This distinct staining pattern supports accurate identification of CD4-positive cells against surrounding epithelial, stromal, and vascular structures. A recombinant rabbit monoclonal CD4 antibody such as clone MSVA-004R can be used in immunohistochemistry to support detection of CD4-expressing immune cells, enabling detailed analysis of tissue-resident lymphocyte populations and immune architecture in both normal and disease settings.<br><br>A full range of CD4 antibody reagents for immunohistochemistry, western blot, and flow cytometry is available on our <a href=../cd4-antibody.html>CD4 Antibody</a> collection page.<br><br>This antibody is also part of a broader collection of <a href='/ihc-antibodies-tissue-microarray-validated.html'>IHC antibodies validated by tissue microarray analysis</a>, supporting consistent staining across normal and cancer tissues.

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