OAT1 Polyclonal Antibody

Multiple cysteine residues are necessary for proper targeting to the plasma membrane.|Involved in the renal elimination of endogenous and exogenous organic anions. Functions as organic anion exchanger when the uptake of one molecule of organic anion is coupled with an efflux of one molecule of endogenous dicarboxylic acid (glutarate| ketoglutarate| etc). Mediates the sodium-independent uptake of 2|3-dimercapto-1-propanesulfonic acid (DMPS) (By similarity). Mediates the sodium-independent uptake of p-aminohippurate (PAH)| ochratoxin (OTA)| acyclovir (ACV)| 3'-azido-3-'deoxythymidine (AZT)| cimetidine (CMD)| 2|4-dichloro-phenoxyacetate (2|4-D)| hippurate (HA)| indoleacetate (IA)| indoxyl sulfate (IS) and 3-carboxy-4-methyl-5-propyl-2-furanpropionate (CMPF)| cidofovir| adefovir| 9-(2-phosphonylmethoxyethyl) guanine (PMEG)| 9-(2-phosphonylmethoxyethyl) diaminopurine (PMEDAP) and edaravone sulfate. PAH uptake is inhibited by p-chloromercuribenzenesulphonate (PCMBS)| diethyl pyrocarbonate (DEPC)| sulindac| diclofenac| carprofen| glutarate and okadaic acid (By similarity). PAH uptake is inhibited by benzothiazolylcysteine (BTC)| S-chlorotrifluoroethylcysteine (CTFC)| cysteine S-conjugates S-dichlorovinylcysteine (DCVC)| furosemide| steviol| phorbol 12-myristate 13-acetate (PMA)| calcium ionophore A23187| benzylpenicillin| furosemide| indomethacin| bumetamide| losartan| probenecid| phenol red| urate| and alpha-ketoglutarate.|PTM:Glycosylated. Glycosylation at Asn-113 may occur at a secondary level. Glycosylation is necesssary for proper targeting of the transporter to the plasma membrane.|Belongs to the major facilitator superfamily. Organic cation transporter family.|tissue specificity:Strongly expressed in kidney and to a lower extent in liver| skeletal muscle| brain and placenta. Found at the basolateral membrane of the proximal tubule.|

The OAT1 Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of OAT1 protein expression in various biological samples. This antibody is produced using a polyclonal approach, ensuring a diverse range of epitope recognition and enhanced sensitivity. With its exceptional specificity, this antibody enables accurate and reliable analysis of OAT1 protein levels in both research and clinical settings.

The OAT1 Polyclonal Antibody exhibits excellent performance in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It has been extensively validated for its ability to specifically recognize OAT1 protein in a wide range of species, including human, mouse, and rat. This versatility allows for seamless integration into diverse experimental designs and ensures consistent and reproducible results.

This antibody is manufactured using high-quality materials and rigorous quality control measures to guarantee batch-to-batch consistency and reliability. It is supplied as a ready-to-use solution, eliminating the need for time-consuming and error-prone antibody preparation. The OAT1 Polyclonal Antibody offers exceptional sensitivity, enabling the detection of low-abundance OAT1 protein levels with high precision and accuracy.

In summary, the OAT1 Polyclonal Antibody is a valuable tool for researchers and clinicians seeking to investigate the expression and function of OAT1 protein. Its exceptional specificity, sensitivity, and versatility make it an indispensable asset in various applications, facilitating groundbreaking discoveries and advancing our understanding of OAT1-related processes and diseases.