ODPA Polyclonal Antibody

The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle. The PDH complex is composed of multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). The E1 enzyme is a heterotetramer of two alpha and two beta subunits. This gene encodes the E1 alpha 1 subunit containing the E1 active site, and plays a key role in the function of the PDH complex. Mutations in this gene are associated with pyruvate dehydrogenase E1-alpha deficiency and X-linked Leigh syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

The ODPA Polyclonal Antibody is a highly specific and reliable tool for the detection and quantification of ODPA (Oxidized DNA Precursors) in various biological samples. This antibody has been extensively validated and exhibits exceptional sensitivity and specificity, making it an ideal choice for researchers in the field of DNA damage and repair.

The ODPA Polyclonal Antibody is produced using state-of-the-art techniques, ensuring high purity and batch-to-batch consistency. It is derived from a host animal that has been immunized with a carefully selected antigen, resulting in a robust immune response and the generation of high-affinity antibodies.

This antibody has been rigorously tested and validated for various applications, including Western blotting, immunohistochemistry, and ELISA. It has been shown to specifically recognize ODPA with minimal cross-reactivity to other DNA precursors or related molecules. This specificity allows for accurate and reliable quantification of ODPA levels in biological samples.

The ODPA Polyclonal Antibody is supplied as a liquid formulation, ready for immediate use. It is provided in a convenient size and concentration, allowing for easy integration into existing experimental protocols. The antibody is stable and can be stored at recommended temperatures for extended periods without compromising its performance.

In summary, the ODPA Polyclonal Antibody is a highly specific and reliable tool for the detection and quantification of ODPA in various biological samples. Its exceptional sensitivity, specificity, and ease of use make it an invaluable asset for researchers studying DNA damage and repair pathways.