OGG1 Polyclonal Antibody

This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common, which contains a mitochondrial targeting signal that is essential for mitochondrial localization. Many alternative splice variants for this gene have been described, but the full-length nature for every variant has not been determined.

The OGG1 Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of OGG1 protein in various biological samples. This antibody is produced using state-of-the-art techniques, ensuring high affinity and specificity towards the target protein.

OGG1, also known as 8-oxoguanine DNA glycosylase 1, plays a crucial role in the repair of oxidative DNA damage. It is involved in the base excision repair pathway, which is responsible for removing and replacing damaged DNA bases. The OGG1 Polyclonal Antibody recognizes and binds to OGG1 protein, enabling researchers to study its expression levels and localization in different tissues and cell types.

This antibody has been extensively validated for its performance in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It exhibits minimal cross-reactivity with other proteins, ensuring accurate and reliable results. The OGG1 Polyclonal Antibody is suitable for both qualitative and quantitative analysis of OGG1 protein, making it an indispensable tool for researchers studying DNA repair mechanisms and oxidative stress-related diseases.

With its high sensitivity and specificity, the OGG1 Polyclonal Antibody offers researchers a valuable tool for investigating the role of OGG1 in various biological processes. Its robust performance and versatility make it an ideal choice for a wide range of research applications. Order your OGG1 Polyclonal Antibody today and unlock new insights into DNA repair and oxidative stress pathways.