p21 Polyclonal Antibody

This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-cyclin-dependent kinase2 or -cyclin-dependent kinase4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen, a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of cyclin-dependent kinase2, and may be instrumental in the execution of apoptosis following caspase activation. Mice that lac

The P21 Polyclonal Antibody is a highly specific and sensitive immunological reagent designed for the detection and quantification of the P21 protein. This antibody is produced by immunizing animals with a synthetic peptide corresponding to the C-terminal region of the P21 protein. The resulting polyclonal antibody is purified by affinity chromatography and validated for its specificity and sensitivity by various immunoassays.

The P21 protein is a key regulator of cell cycle progression and is involved in the control of cell proliferation, differentiation, and apoptosis. Aberrant expression of P21 has been implicated in various diseases, including cancer, cardiovascular diseases, and neurodegenerative disorders. Therefore, the P21 Polyclonal Antibody is an essential tool for researchers studying the role of P21 in these diseases.

The P21 Polyclonal Antibody is suitable for use in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It is available in different formats and sizes to meet the specific needs of researchers. The antibody is supplied in a convenient and ready-to-use format, making it easy to use in various experimental settings.

In summary, the P21 Polyclonal Antibody is a reliable and high-quality reagent that enables accurate and sensitive detection of the P21 protein. It is an essential tool for researchers studying the role of P21 in various diseases and provides valuable insights into the molecular mechanisms underlying these diseases.