P311 Polyclonal Antibody

P311, also known as C5orf13 (chromosome 5 open reading frame 13), D4S114, PTZ17 or PRO1873, is a 68 amino acid cytoplasmic protein involved in cellular differentiation, neural function and axonal regeneration. Found in the granular layer of the cerebellum, P311 is expressed at lower levels in hippocampus, olfactory bulb, kidney, liver and heart and when expressed ectopically, P311 augments giloma motility. P311 is enriched in mice within the superficial cortical layers and striatum at E20 and the germinal zones at E17. Known to interact with Filamin 1, P311 regulates retinoic-acid lipid-droplet biogenesis, induces myofibroblast ameboid migration and the differentiation of fibroblasts into myofibroblasts. Ser-59 phosphorylation decreases P311 stability; the gene encoding P311 maps to human chromosome 5q22.

The P311 Polyclonal Antibody is a highly specific and sensitive immunological reagent designed for use in a variety of research applications. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to a unique sequence of the human P311 protein. The resulting polyclonal antibody is purified using a combination of protein A and protein G affinity chromatography, ensuring high purity and specificity.

The P311 Polyclonal Antibody has been extensively validated for use in Western blotting, immunohistochemistry, and immunofluorescence assays. It has been shown to specifically recognize the P311 protein in a variety of human and animal tissues, making it an ideal tool for studying the expression and function of this protein in various biological systems.

This antibody is supplied as a liquid formulation in phosphate-buffered saline (PBS) with 0.02% sodium azide as a preservative. It is available in various sizes to meet the needs of different research applications. The P311 Polyclonal Antibody is a reliable and high-quality reagent that can help researchers advance their understanding of the P311 protein and its role in various biological processes.