p38(Phospho Thr180/Y182) Polyclonal Antibody

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals| and are involved in a wide variety of cellular processes such as proliferation| differentiation| transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs)| or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2| MEF2C| and MAX| cell cycle regulator CDC25B| and tumor suppressor p53| which suggest the roles of this kinase in stress related transcription and cell cycle regulation| as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding d

The p38(Phospho Thr180/Y182) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of phosphorylated p38 protein at Thr180 and Y182 residues. This antibody is produced using advanced techniques and high-quality materials to ensure optimal performance and reliability.

The p38 protein, a member of the mitogen-activated protein kinase (MAPK) family, plays a crucial role in various cellular processes, including cell proliferation, differentiation, and apoptosis. Phosphorylation of p38 at Thr180 and Y182 residues is known to activate its kinase activity, leading to downstream signaling events.

This polyclonal antibody has been extensively validated for its specificity and sensitivity in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It exhibits minimal cross-reactivity with non-phosphorylated p38 protein, ensuring accurate and reliable results.

With its high affinity and specificity, the p38(Phospho Thr180/Y182) Polyclonal Antibody is an indispensable tool for researchers studying the role of p38 signaling pathway in various physiological and pathological conditions. Its superior performance and consistent results make it an ideal choice for both basic research and drug development studies.

Order your p38(Phospho Thr180/Y182) Polyclonal Antibody today and unlock new insights into the intricate mechanisms of p38 signaling pathway.