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ELK Biotechnology
SKU(재고 관리 코드):ES10785
P3C2A Rabbit Polyclonal Antibody
P3C2A Rabbit Polyclonal Antibody
P3C2A Rabbit Polyclonal Antibody
Overview
| Product name: | P3C2A rabbit pAb |
| Applications: | WB;ELISA |
| Recommended Dilutions: | WB 1:500-2000 ELISA 1:5000-20000 |
| Immunogen: | Synthesized peptide derived from part region of human protein |
| Storage: | Rabbit |
| Storage: | -20°C/1 year |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Concentration: | 1 mg/ml |
| Observed Band: | 185kD |
| GeneID（Human）: | 5286 |
| Human Swiss-Prot No: | O00443 |
| Cellular localization: | Cell membrane . Cytoplasmic vesicle, clathrin-coated vesicle . Nucleus . Cytoplasm . Golgi apparatus, trans-Golgi network . Inserts preferentially into membranes containing PtdIns(4,5)P2 (PubMed:17038310). Associated with RNA-containing structures (PubMed:11606566). . |
| Background: | The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is not sensitive to nanomolar levels of the inhibitor wortmanin. This protein was shown to be able to be activated by insulin and may be involved in integrin-dependent signaling. [provided by RefSeq, Jul 2008], |
| Species Reactivity: | Human;Mouse |
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