p63(Phospho Ser455) Polyclonal Antibody

This gene encodes a member of the p53 family of transcription factors. The functional domains of p53 family proteins include an N-terminal transactivation domain, a central DNA-binding domain and an oligomerization domain. Alternative splicing of this gene and the use of alternative promoters results in multiple transcript variants encoding different isoforms that vary in their functional properties. These isoforms function during skin development and maintenance, adult stem/progenitor cell regulation, heart development and premature aging. Some isoforms have been found to protect the germline by eliminating oocytes or testicular germ cells that have suffered DNA damage. Mutations in this gene are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3); split-hand/foot malformation 4 (SHFM4); ankyloblepharon-ectodermal defects-cleft lip/palate; ADULT syndrome (acro-dermato-ungual-lacrim

The p63(Phospho Ser455) Polyclonal Antibody is a highly specific and sensitive tool for the detection and quantification of p63 protein phosphorylated at Ser455. This antibody has been rigorously validated for use in various applications, including Western blotting, immunohistochemistry, and immunofluorescence.

The p63 protein is a member of the p53 family and plays a crucial role in the regulation of cell proliferation, differentiation, and apoptosis. Phosphorylation of p63 at Ser455 has been implicated in the modulation of its transcriptional activity and downstream signaling pathways.

Our p63(Phospho Ser455) Polyclonal Antibody has been developed using state-of-the-art techniques and exhibits exceptional specificity and sensitivity. It has been extensively tested and validated to ensure reliable and reproducible results.

This antibody is supplied as a liquid formulation, ready for immediate use. It is provided in a convenient size and concentration, allowing for easy handling and storage. The antibody is suitable for use with a variety of sample types, including cell lysates, tissue extracts, and cultured cells.

When used in Western blotting, the p63(Phospho Ser455) Polyclonal Antibody demonstrates a strong and specific signal at the expected molecular weight of the phosphorylated p63 protein. It exhibits minimal cross-reactivity with non-phosphorylated p63 and other related proteins, ensuring accurate and reliable detection.

In immunohistochemistry and immunofluorescence applications, this antibody shows excellent staining patterns and high signal-to-noise ratios. It allows for precise localization and visualization of phosphorylated p63 protein in various tissue types and cellular compartments.

Overall, the p63(Phospho Ser455) Polyclonal Antibody is a valuable tool for researchers studying the role of p63 phosphorylation in cellular processes. Its high specificity, sensitivity, and versatility make it an essential component of any study involving p63 protein analysis.