PAPP1 Polyclonal Antibody

This gene encodes a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs). It is thought to be involved in local proliferative processes such as wound healing and bone remodeling. Low plasma level of this protein has been suggested as a biochemical marker for pregnancies with aneuploid fetuses.

The PAPP1 Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of PAPP1 protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to a specific region of the PAPP1 protein.

PAPP1, also known as pregnancy-associated plasma protein A1, is a metalloproteinase that plays a crucial role in the regulation of insulin-like growth factor (IGF) signaling pathway. It is involved in the proteolytic cleavage of IGF-binding proteins (IGFBPs), leading to the release of bioactive IGFs. Dysregulation of PAPP1 expression has been implicated in various pathological conditions, including cancer, cardiovascular diseases, and metabolic disorders.

The PAPP1 Polyclonal Antibody has been rigorously validated for its specificity and sensitivity in various experimental settings, including Western blotting, immunohistochemistry, and immunofluorescence. It exhibits minimal cross-reactivity with other related proteins, ensuring accurate and reliable results.

This antibody is supplied as a liquid formulation in a convenient size of 100 µg, allowing for multiple experiments. It is recommended to store the antibody at -20°C for long-term stability. Prior to use, it is advised to aliquot the antibody to avoid repeated freeze-thaw cycles.

In summary, the PAPP1 Polyclonal Antibody is a valuable tool for researchers studying the role of PAPP1 in various biological processes. Its high specificity, sensitivity, and versatility make it an ideal choice for a wide range of applications, enabling precise and reliable detection and quantification of PAPP1 protein.