PAX3 Polyclonal Antibody

This gene is a member of the paired box (PAX) family of transcription factors. Members of the PAX family typically contain a paired box domain and a paired-type homeodomain. These genes play critical roles during fetal development. Mutations in paired box gene 3 are associated with Waardenburg syndrome, craniofacial-deafness-hand syndrome, and alveolar rhabdomyosarcoma. The translocation t(2;13)(q35;q14), which represents a fusion between PAX3 and the forkhead gene, is a frequent finding in alveolar rhabdomyosarcoma. Alternative splicing results in transcripts encoding isoforms with different C-termini.

The PAX3 Polyclonal Antibody is a highly reliable and efficient tool for the detection and analysis of PAX3 protein expression in various biological samples. This antibody is produced using advanced techniques, ensuring its high specificity and sensitivity. It has been extensively validated for use in immunohistochemistry (IHC), immunofluorescence (IF), and western blotting (WB) applications.

The PAX3 Polyclonal Antibody exhibits exceptional performance in detecting endogenous levels of PAX3 protein in a wide range of species, including human, mouse, and rat. It recognizes an epitope within the N-terminal region of the PAX3 protein, making it an ideal choice for studying the expression and localization of this transcription factor.

With its superior sensitivity, this antibody enables accurate and precise quantification of PAX3 protein levels in various tissues and cell lines. Its robust performance ensures reliable and reproducible results, making it an indispensable tool for researchers in the fields of developmental biology, cancer research, and regenerative medicine.

The PAX3 Polyclonal Antibody is supplied as a liquid formulation, allowing for easy and convenient handling. It is provided in a ready-to-use format, eliminating the need for time-consuming and complex preparation steps. The antibody is also available in different sizes to accommodate various experimental needs.

In summary, the PAX3 Polyclonal Antibody is a highly specific and sensitive tool for the detection and analysis of PAX3 protein expression. Its exceptional performance, ease of use, and versatility make it an invaluable asset for researchers seeking to unravel the intricate mechanisms underlying PAX3-mediated processes.