PDHK1(Phospho Thr338) Rabbit Polyclonal Antibody

Pyruvate dehydrogenase (PDH) is a mitochondrial multienzyme complex that catalyzes the oxidative decarboxylation of pyruvate and is one of the major enzymes responsible for the regulation of homeostasis of carbohydrate fuels in mammals. The enzymatic activity is regulated by a phosphorylation/dephosphorylation cycle. Phosphorylation of PDH by a specific pyruvate dehydrogenase kinase (PDK) results in inactivation. Multiple alternatively spliced transcript variants have been found for this gene.

The PDHK1 (Phospho Thr338) Rabbit Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of PDHK1 protein phosphorylated at Thr338 residue. This antibody is produced using high-quality rabbit polyclonal antibodies, ensuring excellent performance and reliability in various applications, including Western blotting, immunoprecipitation, and immunofluorescence.

PDHK1, also known as pyruvate dehydrogenase kinase 1, plays a crucial role in regulating the activity of pyruvate dehydrogenase complex (PDC), a key enzyme complex involved in glucose metabolism. Phosphorylation of PDHK1 at Thr338 residue is known to enhance its kinase activity, leading to the inhibition of PDC and subsequent suppression of glucose oxidation.

The PDHK1 (Phospho Thr338) Rabbit Polyclonal Antibody has been extensively validated for its specificity and sensitivity in detecting phosphorylated PDHK1 at Thr338 residue. It exhibits minimal cross-reactivity with non-phosphorylated PDHK1 and other related proteins, ensuring accurate and reliable results.

This antibody is supplied as a liquid formulation, ready to use for various experimental procedures. It has been optimized for use in a wide range of sample types, including cell lysates, tissue extracts, and purified proteins. The antibody demonstrates excellent performance in Western blotting, providing clear and specific bands at the expected molecular weight of phosphorylated PDHK1.

With its high specificity, sensitivity, and versatility, the PDHK1 (Phospho Thr338) Rabbit Polyclonal Antibody is an indispensable tool for researchers studying the role of PDHK1 phosphorylation in glucose metabolism and related diseases. Its reliable performance and consistent results make it an ideal choice for both basic research and clinical applications.