Perforin 1 Polyclonal Antibody

The protein encoded by PRF1 (perforin 1) has structural and functional similarities to complement component 9 (C9). Like C9, this protein creates transmembrane tubules and is capable of lysing non-specifically a variety of target cells. This protein is one of the main cytolytic proteins of cytolytic granules, and it is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis. Defects in PRF1 cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood. Alternative splicing results in multiple transcript variants encoding the same protein.

The Perforin 1 Polyclonal Antibody is a highly specific and sensitive antibody designed for the detection of Perforin 1 protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of human Perforin 1 protein. The antibody has been purified using protein A affinity chromatography and is supplied as a liquid solution in phosphate-buffered saline (PBS) with 0.02% sodium azide as a preservative.

The Perforin 1 Polyclonal Antibody is suitable for use in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It has been validated for use in human, mouse, and rat samples and has been shown to exhibit high specificity and sensitivity in detecting Perforin 1 protein.

This antibody is an essential tool for researchers studying the role of Perforin 1 in various biological processes, including immune response, inflammation, and cancer. Its high specificity and sensitivity make it an ideal choice for detecting low levels of Perforin 1 protein in complex biological samples.

In summary, the Perforin 1 Polyclonal Antibody is a reliable and effective tool for the detection of Perforin 1 protein in various biological samples. Its high specificity and sensitivity make it an essential tool for researchers studying the role of Perforin 1 in various biological processes.