Phospho-Akt2 (S474) Polyclonal Antibody

AKT2 is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains. AKT2 was shown to be amplified and overexpressed in 2 of 8 ovarian carcinoma cell lines and 2 of 15 primary ovarian tumors. Overexpression contributes to the malignant phenotype of a subset of human ductal pancreatic cancers. AKT serine/threonine kinase 2 is a general protein kinase capable of phophorylating several known proteins.

The Phospho-Akt2 (S474) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of phosphorylated Akt2 at serine 474 residue. This antibody is produced using advanced polyclonal antibody technology, ensuring high affinity and specificity towards the target protein.

Phosphorylation of Akt2 at serine 474 plays a crucial role in the regulation of various cellular processes, including cell survival, proliferation, and metabolism. The Phospho-Akt2 (S474) Polyclonal Antibody enables researchers to investigate the activation status of Akt2 and its involvement in signaling pathways associated with cancer, diabetes, and other diseases.

This antibody has been rigorously validated for its performance in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It exhibits exceptional sensitivity and specificity, allowing for accurate and reliable detection of phosphorylated Akt2 in complex biological samples.

The Phospho-Akt2 (S474) Polyclonal Antibody is supplied as a ready-to-use solution, eliminating the need for time-consuming antibody preparation. It is compatible with a wide range of sample types, including cell lysates, tissue extracts, and purified proteins.

With its exceptional performance and versatility, the Phospho-Akt2 (S474) Polyclonal Antibody is an indispensable tool for researchers studying Akt2 signaling and its implications in various physiological and pathological processes.