Phospho-ALK (Y1096) Polyclonal Antibody

ALK encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. ALK tyrosine kinase receptor comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)/EML4 (chromosome 2), ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosome 2), ALK/TFG (chromosome 3), ALK/NPM1 (chromosome 5), ALK/SQSTM1 (chromosome 5), ALK/KIF5B (chromosome 10), ALK/CLTC (chromosome 17), ALK/TPM4 (chromosome 19), and ALK/MSN (chromosome X).

Introducing the Phospho-ALK (Y1096) Polyclonal Antibody, a cutting-edge scientific tool meticulously designed to facilitate accurate detection and analysis of phosphorylated anaplastic lymphoma kinase (ALK) at tyrosine residue 1096. This high-quality antibody is specifically engineered to exhibit exceptional sensitivity and specificity, enabling researchers to delve into the intricate mechanisms underlying ALK signaling pathways.

Crafted with utmost precision, the Phospho-ALK (Y1096) Polyclonal Antibody boasts an advanced formulation that ensures optimal performance across a wide range of applications, including Western blotting, immunoprecipitation, and immunohistochemistry. Its unrivaled affinity for phosphorylated ALK at Y1096 guarantees unparalleled detection sensitivity, enabling researchers to discern even the minutest alterations in ALK phosphorylation levels.

This antibody's polyclonal nature further enhances its versatility, enabling it to recognize multiple epitopes on the target protein, thereby amplifying the signal and facilitating robust detection. Its exceptional specificity ensures minimal cross-reactivity with non-phosphorylated ALK and other related proteins, thereby minimizing false-positive results and ensuring the utmost accuracy in experimental outcomes.

The Phospho-ALK (Y1096) Polyclonal Antibody is meticulously validated through rigorous quality control measures, ensuring consistent and reliable performance across various experimental conditions. Its exceptional stability and long shelf life guarantee prolonged usability, making it an indispensable asset for laboratories and research institutions alike.

In summary, the Phospho-ALK (Y1096) Polyclonal Antibody represents a breakthrough in scientific research, empowering investigators to unravel the complexities of ALK signaling pathways with unprecedented precision and accuracy. With its exceptional sensitivity, specificity, and versatility, this antibody is poised to revolutionize the field of ALK-related research, enabling groundbreaking discoveries and advancements in the understanding and treatment of various diseases.