Phospho-AQP2 (S256) Polyclonal Antibody

AQP2 encodes a water channel protein located in the kidney collecting tubule. It belongs to the MIP/aquaporin family, some members of which are clustered together on chromosome 12q13. Mutations in this gene have been linked to autosomal dominant and recessive forms of nephrogenic diabetes insipidus.

The Phospho-AQP2 (S256) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of phosphorylated Aquaporin-2 (AQP2) protein at serine 256 residue. This antibody is produced using advanced techniques and rigorous quality control measures to ensure optimal performance and reliability.

Aquaporin-2 is a water channel protein primarily expressed in the kidney collecting ducts, where it plays a crucial role in regulating water reabsorption. Phosphorylation of AQP2 at serine 256 residue is a key post-translational modification that modulates its cellular localization and water permeability activity. Therefore, the Phospho-AQP2 (S256) Polyclonal Antibody serves as an invaluable tool for studying the phosphorylation status and functional regulation of AQP2 in various physiological and pathological conditions.

This polyclonal antibody exhibits exceptional specificity towards the phosphorylated form of AQP2 at serine 256 residue, with minimal cross-reactivity to non-phosphorylated AQP2 or other related proteins. It has been extensively validated through various experimental approaches, including Western blotting, immunohistochemistry, and immunofluorescence, ensuring accurate and reproducible results.

The Phospho-AQP2 (S256) Polyclonal Antibody is supplied as a liquid formulation in a convenient size, allowing for easy handling and storage. It is recommended for use in a wide range of applications, including but not limited to, protein expression analysis, cellular localization studies, and functional characterization of AQP2 phosphorylation.

In summary, the Phospho-AQP2 (S256) Polyclonal Antibody is a reliable and high-quality reagent that enables precise detection and quantification of phosphorylated AQP2 at serine 256 residue. Its exceptional specificity, sensitivity, and versatility make it an indispensable tool for researchers and scientists working in the field of renal physiology, water homeostasis, and related areas of study.