Phospho-ASK 1 (S966) Polyclonal Antibody

Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MAPKKK5 contains 1,374 amino acids with all 11 kinase subdomains. Northern blot analysis shows that MAPKKK5 transcript is abundantly expressed in human heart and pancreas. The MAPKKK5 protein phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) during transient expression in COS and 293 cells; MAPKKK5 does not activate MAPK/ERK.

Introducing the Phospho-ASK 1 (S966) Polyclonal Antibody, a cutting-edge scientific tool meticulously designed to facilitate advanced research in the field of molecular biology. This antibody, derived from a polyclonal source, exhibits exceptional specificity and sensitivity, enabling precise detection and analysis of ASK 1 phosphorylation at serine 966 residue.

Crafted with utmost precision and utilizing state-of-the-art technology, the Phospho-ASK 1 (S966) Polyclonal Antibody offers researchers an invaluable resource to unravel the intricate mechanisms underlying cellular signaling pathways. By targeting the phosphorylation event at serine 966, this antibody empowers investigators to gain deeper insights into the functional implications of ASK 1 activation and its subsequent downstream signaling cascades.

With its unparalleled affinity and selectivity, this antibody ensures accurate and reliable results, facilitating the elucidation of ASK 1-mediated cellular processes. Its exceptional performance in various applications, including Western blotting, immunoprecipitation, and immunofluorescence, further enhances its versatility and utility in diverse experimental settings.

The Phospho-ASK 1 (S966) Polyclonal Antibody is meticulously validated through rigorous quality control measures, guaranteeing consistent and reproducible outcomes. Its robust performance across multiple species, including human, mouse, and rat, broadens its applicability and enables cross-species comparative studies.

In summary, the Phospho-ASK 1 (S966) Polyclonal Antibody represents a breakthrough tool for researchers seeking to unravel the complexities of ASK 1 signaling. Its exceptional specificity, sensitivity, and versatility make it an indispensable asset in the pursuit of scientific discovery and advancement in the realm of molecular biology.