Phospho-Caspase-9 (Y153) Polyclonal Antibody

CASP9 (caspase 9) encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein can undergo autoproteolytic processing and activation by the apoptosome, a protein complex of cytochrome c and the apoptotic peptidase activating factor 1; this step is thought to be one of the earliest in the caspase activation cascade. This protein is thought to play a central role in apoptosis and to be a tumor suppressor. Alternative splicing results in multiple transcript variants.

The Phospho-Caspase-9 (Y153) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of phosphorylated Caspase-9 at tyrosine 153 residue. This antibody is produced using advanced immunization techniques, ensuring high affinity and specificity towards the target protein.

Caspase-9 is a crucial enzyme involved in the initiation of apoptosis, a programmed cell death process. Phosphorylation of Caspase-9 at tyrosine 153 has been identified as a key regulatory event in the activation of this enzyme. Therefore, the Phospho-Caspase-9 (Y153) Polyclonal Antibody serves as an invaluable tool for researchers studying apoptosis and its regulation.

This antibody has been extensively validated for various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It exhibits exceptional sensitivity and specificity, enabling accurate and reliable detection of phosphorylated Caspase-9 in a wide range of sample types.

The Phospho-Caspase-9 (Y153) Polyclonal Antibody is supplied as a ready-to-use solution, eliminating the need for time-consuming and error-prone antibody preparation. It is provided in a convenient size, ensuring cost-effectiveness and minimizing wastage.

With its exceptional performance and reliability, the Phospho-Caspase-9 (Y153) Polyclonal Antibody is an indispensable tool for researchers investigating apoptosis and its intricate regulatory mechanisms.