Phospho-Caveolin-1 (Y14) Polyclonal Antibody

The scaffolding protein (caveolin 1) encoded by CAV1 is the main component of the caveolae plasma membranes found in most cell types. Caveolin 1 links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. CAV1 is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 mitogen-activated kinase cascade. Caveolin 1 and caveolin 2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. Mutations in CAV1 have been associated with Berardinelli-Seip congenital lipodystrophy. Alternatively spliced transcripts encode alpha and beta isoforms of caveolin 1.

The Phospho-Caveolin-1 (Y14) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of phosphorylated Caveolin-1 protein. This antibody is produced using advanced techniques, ensuring its high affinity and specificity towards the phosphorylated form of Caveolin-1 at tyrosine 14 residue.

Caveolin-1 is a key structural protein found in caveolae, specialized lipid rafts present in the plasma membrane. It plays a crucial role in various cellular processes, including signal transduction, endocytosis, and cholesterol homeostasis. Phosphorylation of Caveolin-1 at tyrosine 14 has been implicated in the regulation of its function and cellular signaling pathways.

The Phospho-Caveolin-1 (Y14) Polyclonal Antibody has been extensively validated for its performance in various applications, including Western blotting, immunoprecipitation, and immunofluorescence. It exhibits exceptional sensitivity and specificity, enabling accurate detection and quantification of phosphorylated Caveolin-1 in complex biological samples.

This antibody is supplied as a liquid formulation, ready for immediate use. It is provided in a convenient size, ensuring cost-effectiveness and minimizing wastage. The Phospho-Caveolin-1 (Y14) Polyclonal Antibody is compatible with a wide range of experimental conditions and can be used in diverse research areas, such as cancer biology, cell signaling, and membrane dynamics.

With its superior performance and reliability, the Phospho-Caveolin-1 (Y14) Polyclonal Antibody is an indispensable tool for scientists and researchers aiming to investigate the role of phosphorylated Caveolin-1 in cellular processes and disease mechanisms. Trust in its exceptional quality and accuracy to advance your research and contribute to scientific discoveries.