Phospho PKC theta (Y90) Rabbit Polyclonal Antibody

Catalytic activity:ATP + a protein = ADP + a phosphoprotein.|cofactor:Magnesium.|The C1 domain| containing the phorbol ester/DAG-type region 1 (C1A) and 2 (C1B)| is the diacylglycerol sensor and the C2 domain is a non-calcium binding domain.|enzyme regulation:Three specific sites; Thr-538 (activation loop of the kinase domain)| Ser-676 (turn motif) and Ser-695 (hydrophobic region)| need to be phosphorylated for its full activation.|PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters| a class of tumor promoters.|This is a calcium-independent| phospholipid-dependent| serine- and threonine-specific enzyme. Essential for T-cell receptor (TCR)-mediated T-cell activation| but is dispensable during TCR-dependent thymocyte development. Links the TCR signaling complex to the activation of NF-kappa-B in mature T lymphocytes. Required for interleukin-2 (IL2) production.|PTM:Autophosphorylation at Thr-219 is required for targeting to the TCR and cellular function of PKC upon antigen receptor ligation.|Belongs to the protein kinase superfamily.|Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.|Contains 1 AGC-kinase C-terminal domain.|Contains 1 C2 domain.|Contains 1 protein kinase domain.|Contains 2 phorbol-ester/DAG-type zinc fingers.|subunit:Interacts with TXNL2/PICOT.|tissue specificity:Skeletal muscle| megakaryoblastic cells and platelets.|

Introducing the PHOSPHO PKC THETA (Y90) Rabbit Polyclonal Antibody, a highly specific and sensitive tool for the detection of phosphorylated PKC Theta in various biological samples. This antibody is produced using high-quality rabbit polyclonal antibodies and is designed to recognize and bind to the phosphorylated form of PKC Theta at tyrosine 90 residue.

The PHOSPHO PKC THETA (Y90) Rabbit Polyclonal Antibody is ideal for use in a wide range of applications, including Western blotting, immunoprecipitation, and immunohistochemistry. It has been extensively validated for its specificity and sensitivity, ensuring reliable and reproducible results.

This antibody is supplied in a convenient and easy-to-use format, with a concentration of 1 mg/mL. It is also available in different sizes to suit your specific needs.

In summary, the PHOSPHO PKC THETA (Y90) Rabbit Polyclonal Antibody is a valuable tool for researchers studying PKC Theta signaling pathways and its role in various biological processes. Its high specificity and sensitivity make it an excellent choice for a wide range of applications, providing reliable and reproducible results.