PKA I Alpha reg Polyclonal Antibody

cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. PRKAR1A encodes one of the regulatory subunits. Protein kinase cAMP-dependent type I regulatory subunit alpha was found to be a tissue-specific extinguisher that down-regulates the expression of seven liver genes in hepatoma x fibroblast hybrids. Mutations in PRKAR1A cause Carney complex (CNC). PRKAR1A can fuse to the RET protooncogene by gene rearrangement and form the thyroid tumor-specific chimeric oncogene known as PTC2. A nonconventional nuclear localization sequence (NLS) has been found for protein kinase cAMP-dependent type I regulatory subunit alpha which suggests a role in DNA replication via the protein serving as a nuclear transport protein for the second subunit of the Replication Factor C (RFC40). Several alternatively spliced transcript variants encoding two different isoforms have been observed.

The PKA I Alpha reg Polyclonal Antibody is a highly reliable and efficient tool designed for the detection and analysis of PKA I Alpha reg protein. This antibody is produced using advanced polyclonal antibody technology, ensuring exceptional specificity and sensitivity in various applications.

The PKA I Alpha reg Polyclonal Antibody exhibits outstanding performance in immunohistochemistry (IHC), immunofluorescence (IF), and western blotting (WB) techniques. It enables precise identification and localization of PKA I Alpha reg protein in tissue samples, cell cultures, and other biological specimens.

With its superior affinity and selectivity, this antibody guarantees accurate and reproducible results, making it an indispensable asset for researchers and scientists in the field of protein analysis. Its robustness and versatility allow for a wide range of experimental conditions, facilitating comprehensive investigations into the function and regulation of PKA I Alpha reg protein.

Furthermore, the PKA I Alpha reg Polyclonal Antibody is manufactured under stringent quality control measures, ensuring batch-to-batch consistency and reliability. It is supplied in a convenient and user-friendly format, enabling seamless integration into laboratory workflows.

In summary, the PKA I Alpha reg Polyclonal Antibody is a cutting-edge research tool that offers exceptional performance and reliability in the detection and analysis of PKA I Alpha reg protein. Its advanced technology, combined with its ease of use, makes it an invaluable asset for scientists and researchers seeking to unravel the complexities of PKA I Alpha reg protein in various biological contexts.