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SKU(재고 관리 코드):PAN576Hu01

Polyclonal Antibody to Fibronectin Type III Domain Containing Protein 5 (FNDC5)

Polyclonal Antibody to Fibronectin Type III Domain Containing Protein 5 (FNDC5)

UOM
Concentration
Organism species
Western blotting: 0.5-2µg/mL;
;Immunohistochemistry: 5-20µg/mL;
;Immunocytochemistry: 5-20µg/mL;
;Optimal working dilutions must be determined by end user.

Product No.

PAN576Hu01

Organism Species

Homo sapiens (Human).

Source

Polyclonal antibody preparation

Host

Rabbit

Potency

n/a

Ig Type

IgG

Purification

Antigen-specific affinity chromatography followed by Protein A affinity chromatography

Label

None

Immunogen

RPN576Hu01-Recombinant Fibronectin Type III Domain Containing Protein 5 (FNDC5)

Buffer Formulation

0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.

Traits

Liquid

Concentration

500µg/mL

Organism Species More

Mus musculus (Mouse), Rattus norvegicus (Rat), Sus scrofa; Porcine (Pig)

Applications

WB; IHC; ICC; IP.

If the antibody is used in flow cytometry, please check FCM antibodies.

UOM

20µl 100µl 200µl 1ml 10ml

SPECIFITY

The antibody is a rabbit polyclonal antibody raised against FNDC5. It has been selected for its ability to recognize FNDC5 in immunohistochemical staining and western blotting.

USAGE

Western blotting: 0.5-2µg/mL;
Immunohistochemistry: 5-20µg/mL;
Immunocytochemistry: 5-20µg/mL;
Optimal working dilutions must be determined by end user.

STORAGE

Store at 4°C for frequent use. Stored at -20°C in a manual defrost freezer for two year without detectable loss of activity. Avoid repeated freeze-thaw cycles.

STABILITY

The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

Magazine Citations
Diabetes Research and Clinical Practice Serum irisin levels in new-onset type 2 diabetes PubMed: 23369227
Journal of diabetes and its complications Lower circulating irisin is associated with type 2 diabetes mellitus Pubmed: 23619195
Horm Metab Res. Inconsistency in circulating irisin levels: what is really happening Pubmed:24459033
Int J Obes (Lond). Leptin administration activates irisin-induced myogenesis via nitric oxide-dependent mechanisms, but reduces its effect on subcutaneous fat browning in mice Pubmed:25199621
Molecular and Cellular Endocrinology Fenofibrate (PPARalpha agonist) induces beige cell formation in subcutaneous white adipose tissue from diet-induced male obese mice Pubmed:25576856
journal of diabetes Lower irisin level in patients with type 2 diabetes mellitus: A case-control study and meta-analysis PubMed: 25494632
The Journal of Maternal-Fetal & Neonatal Medicine Maternal circulating levels of irisin in intrahepatic cholestasis of pregnancy PubMed: 26689349
Hormone and Metabolic Research Lower Circulating Irisin Level in Patients with Diabetes Mellitus: A Systematic Review and Meta-Analysis Pubmed:27300472
Nature Reviews Endocrinology Physiology and role of irisin in glucose homeostasis. pubmed:28211512
Journal of Molecular and Cellular Cardiology Irisin improves perivascular adipose tissue dysfunction via regulation of the heme oxygenase-1/adiponectin axis in diet-induced obese mice pubmed:27638193
Biochemical and Biophysical Research Communications Irisin stimulates cell proliferation and invasion by targeting the PI3K/AKT pathway in human hepatocellular carcinoma pubmed:28867187
PLoS One Differential actions of PPAR-α and PPAR-β/δ on beige adipocyte formation: A study in the subcutaneous white adipose tissue of obese male mice Pubmed:29351550
International Brazilian Journal of Urology The Diagnostic Value of FNDC5/Irisin in Renal Cell Cancer. Pubmed:29522296
Redox Biology Irisin alleviates liver ischemia-reperfusion injury by inhibiting excessive mitochondrial fission, promoting mitochondrial biogenesis and decreasing oxidative … Doi: 10.1016/j.redox.2018.10.019
Antioxidants & redox signaling Low serum irisin concentration is associated with poor outcomes in patients with acute pancreatitis and irisin administration protects against experimental acute … Pubmed: 31250660
Journal of Maternal-Fetal & Neonatal Medicine Maternal serum, placental, and umbilical venous blood irisin levels in intrahepatic cholestasis of pregnancy Pubmed: 31590596
Biomed Pharmacother Identification of irisin as a therapeutic agent that inhibits oxidative stress and fibrosis in a murine model of chronic pancreatitis Pubmed: 32199226
Irisin Improves Autophagy of Aged Hepatocytes via Increasing Telomerase Activity in Liver Injury Pubmed: 31976032
Serum Irisin Predicts Posthepatectomy Complications in Patients with Hepatocellular Carcinoma Pubmed: 31976024
DOMESTIC ANIMAL ENDOCRINOLOGY The myokine Irisin: localization and effects in swine late medium and large antral ovarian follicle Pubmed: 33120167
Journal of Biomaterials and Tissue Engineering The Combination of Aerobic and Resistance Exercise Induces Weight Loss via the PGC-1α/Irisin/UCP-1 Pathway
Evaluation of a recombinant bacillus calmette-guérin vaccine expressing P39-L7/L12 of Brucella melitensis: An immunization strategy against brucellosis in BALB/c …
Eur Rev Med Pharmacol Sci Salivary Irisin: potential inflammatory biomarker in recurrent apthous stomatitis patients 33755963
Metabolites Pattern of Adiponectin, Osteocalcin, Irisin, FGF-21, and MCP-1 According to the Body Size Phenotype: Could They Be Markers of Metabolic Health in Mexican-Mestizo … 34822430
Eat Weight Disord Time-restricted feeding prevents metabolic diseases through the regulation of galanin/GALR1 expression in the hypothalamus of mice 34370270
Ir J Med Sci Eight-week exercise program improved the quality of life of Alzheimer's patients through functional, cognitive, and biochemical parameters Pubmed:35604540
Biomed Pharmacother Irisin attenuates sepsis-induced cardiac dysfunction by attenuating inflammation-induced pyroptosis through a mitochondrial ubiquitin ligase-dependent … Pubmed:35653888
Journal of King Saud University - Science Interaction of nitric oxide synthase and mitochondrial ATP-sensitive potassium channels in protective impacts of combination therapy with irisin …
Catalog No. Related products for research use of Homo sapiens (Human) Organism species Applications (RESEARCH USE ONLY!)
RPN576Hu05 Recombinant Fibronectin Type III Domain Containing Protein 5 (FNDC5) Positive Control; Immunogen; SDS-PAGE; WB.
RPN576Hu06 Recombinant Fibronectin Type III Domain Containing Protein 5 (FNDC5) Positive Control; Immunogen; SDS-PAGE; WB.
RPN576Hu07 Recombinant Fibronectin Type III Domain Containing Protein 5 (FNDC5) Positive Control; Immunogen; SDS-PAGE; WB.
RPN576Hu02 Recombinant Fibronectin Type III Domain Containing Protein 5 (FNDC5) Positive Control; Immunogen; SDS-PAGE; WB.
EPN576Hu61 Eukaryotic Fibronectin Type III Domain Containing Protein 5 (FNDC5) Positive Control; Immunogen; SDS-PAGE; WB.
RPN576Hu03 Recombinant Fibronectin Type III Domain Containing Protein 5 (FNDC5) Positive Control; Immunogen; SDS-PAGE; WB.
RPN576Hu01 Recombinant Fibronectin Type III Domain Containing Protein 5 (FNDC5) Positive Control; Immunogen; SDS-PAGE; WB.
APN576Hu01 Active Fibronectin Type III Domain Containing Protein 5 (FNDC5) Cell culture; Activity Assays.
APN576Hu61 Active Fibronectin Type III Domain Containing Protein 5 (FNDC5) Cell culture; Activity Assays.
RPN576Hu04 Recombinant Fibronectin Type III Domain Containing Protein 5 (FNDC5) Positive Control; Immunogen; SDS-PAGE; WB.
PAN576Hu02 Polyclonal Antibody to Fibronectin Type III Domain Containing Protein 5 (FNDC5) WB; IHC; ICC; IP.
PAN576Hu04 Polyclonal Antibody to Fibronectin Type III Domain Containing Protein 5 (FNDC5) WB; IHC; ICC; IP.
PAN576Hu01 Polyclonal Antibody to Fibronectin Type III Domain Containing Protein 5 (FNDC5) WB; IHC; ICC; IP.
LAN576Hu71 Biotin-Linked Polyclonal Antibody to Fibronectin Type III Domain Containing Protein 5 (FNDC5) WB; IHC; ICC.
SEN576Hu ELISA Kit for Fibronectin Type III Domain Containing Protein 5 (FNDC5) Enzyme-linked immunosorbent assay for Antigen Detection.
LMN576Hu Magnetic Luminex Assay Kit for Fibronectin Type III Domain Containing Protein 5 (FNDC5) ,etc. Magnetic Luminex Assay for Antigen Detection.

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