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SKU(재고 관리 코드):PAA819Ca01

Polyclonal Antibody to Parathyroid Hormone Related Protein (PTHrP)

Polyclonal Antibody to Parathyroid Hormone Related Protein (PTHrP)

UOM
Concentration
Organism species

Western blotting: 0.5-2µg/mL;
Immunohistochemistry: 5-20µg/mL;
Immunocytochemistry: 5-20µg/mL;
Optimal working dilutions must be determined by end user.

Product No.

PAA819Ca01

Organism Species

Canis familiaris; Canine (Dog).

Source

Polyclonal antibody preparation

Host

Rabbit

Potency

n/a

Ig Type

IgG

Purification

Antigen-specific affinity chromatography followed by Protein A affinity chromatography

Label

None

Immunogen

RPA819Ca01-Recombinant Parathyroid Hormone Related Protein (PTHrP)

Buffer Formulation

PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.

Traits

Liquid

Concentration

500µg/mL

Organism Species More

Homo sapiens (Human), Mus musculus (Mouse), Rattus norvegicus (Rat)

Applications

WB; IHC; ICC; IP.

If the antibody is used in flow cytometry, please check FCM antibodies.

UOM

20µl 100µl 200µl 1ml 10ml

SPECIFITY

The antibody is a rabbit polyclonal antibody raised against PTHrP. It has been selected for its ability to recognize PTHrP in immunohistochemical staining and western blotting.

USAGE

Western blotting: 0.5-2µg/mL;
Immunohistochemistry: 5-20µg/mL;
Immunocytochemistry: 5-20µg/mL;
Optimal working dilutions must be determined by end user.

STORAGE

Store at 4°C for frequent use. Stored at -20°C in a manual defrost freezer for two year without detectable loss of activity. Avoid repeated freeze-thaw cycles.

STABILITY

The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

Magazine

Citations

Clinical and Experimental Metastasis

Characterization of a new renal cell carcinoma bone metastasis mouse model PubMed: 20443133

Stem Cells and Development

Temporal activation of β-catenin signaling in the chondrogenic process of mesenchymal stem cells affects the phenotype of the cartilage generated. PubMed: 22133004

International journal of biological sciences

PTHrP Expression in Human MDA-MB-231 Breast Cancer Cells Is Critical for Tumor Growth and Survival and Osteoblast Inhibition PubMed: PMC3753447

Investigational New Drugs

Tetrahydrofurofuran-type lignans inhibit breast cancer-mediated bone destruction by blocking the vicious cycle between cancer cells, osteoblasts and osteoclasts Pubmed: 23673814

Toxicology and Applied Pharmacology

Betulinic acid, a bioactive pentacyclic triterpenoid, inhibits skeletal-related events induced by breast cancer bone metastases and treatment Pubmed:24463094

Arch Gynecol Obstet.

Calcitonin gene-and parathyroid hormone-related peptides in normotensive and preeclamptic pregnancies: a nested case–control study Pubmed:24943060

PLoS One

15-Deoxy-Δ12, 14-Prostaglandin J2 Inhibits Osteolytic Breast Cancer Bone Metastasis and Estrogen Deficiency-Induced Bone Loss PubMed: 25859665

Endocrinology

A role for the calcitonin receptor to limit bone loss during lactation in female mice by inhibiting osteocytic osteolysis PubMed: 26135836

Tumour Biol

Osteopontin expression in co-cultures of human squamous cell carcinoma-derived cells and osteoblastic cells and its effects on the neoplastic cell phenotype and osteoclastic activation. Pubmed:27312487

35

Hedgehog signaling in bone regulates whole-body energy metabolism through a bone–adipose endocrine relay mediated by PTHrP and adiponectin pubmed:27740628

Bone

Lactation induces increases in the RANK/RANKL/OPG system in maxillary bone Pubmed:29382610

International Journal of Molecular Sciences

A Diet Rich in Fish Oil and Leucine Ameliorates Hypercalcemia in Tumour-Induced Cachectic Mice Pubmed: 31600911

Journal of Orthopaedic Surgery and Research

Identification of a potential gene target for osteoarthritis based on bioinformatics analyses Pubmed: 32571421

International Immunopharmacology

Parathyroid hormone related protein (PTHrP)-mediated hypercalcemia in malignancy associated with anti-PD-1 immune checkpoint inhibitor treatment and related …


Паратиреоидный гормон-родственный протеин как предиктор развития мочекаменной болезни

Cell Death Dis

Extracellular vesicles-released parathyroid hormone-related protein from Lewis lung carcinoma induces lipolysis and adipose tissue browning in cancer ¡­ 33510128

Sci Rep

Effects of whole-body vibration training in a cachectic C26 mouse model 34732809

Acta Physiologica

The acute adaptation of renal phosphate transporters in the murine kidney to oral phosphate intake requires multiple signals Pubmed:35334154


Catalog No.

Related products for research use of Canis familiaris; Canine (Dog) Organism species

Applications (RESEARCH USE ONLY!)

RPA819Ca01

Recombinant Parathyroid Hormone Related Protein (PTHrP)

Positive Control; Immunogen; SDS-PAGE; WB.

PAA819Ca01

Polyclonal Antibody to Parathyroid Hormone Related Protein (PTHrP)

WB; IHC; ICC; IP.

LAA819Ca71

Biotin-Linked Polyclonal Antibody to Parathyroid Hormone Related Protein (PTHrP)

WB; IHC; ICC.

MAA819Ca21

Monoclonal Antibody to Parathyroid Hormone Related Protein (PTHrP)

WB; IHC; ICC; IP.

 

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