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SKU(재고 관리 코드):PAE912Hu01

Polyclonal Antibody to Sirtuin 1 (SIRT1)

Polyclonal Antibody to Sirtuin 1 (SIRT1)

UOM
Concentration
Organism species

Western blotting: 0.5-2µg/mL;
Immunohistochemistry: 5-20µg/mL;
Immunocytochemistry: 5-20µg/mL;
Optimal working dilutions must be determined by end user.

Product No.

PAE912Hu01

Organism Species

Homo sapiens (Human).

Source

Polyclonal antibody preparation

Host

Rabbit

Potency

n/a

Ig Type

IgG

Purification

Antigen-specific affinity chromatography followed by Protein A affinity chromatography

Label

None

Immunogen

RPE912Hu01-Recombinant Sirtuin 1 (SIRT1)

Buffer Formulation

0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.

Traits

Liquid

Concentration

0.29mg/ml

Organism Species More

Mus musculus (Mouse), Rattus norvegicus (Rat)

Applications

WB; IHC; ICC; IP.

If the antibody is used in flow cytometry, please check FCM antibodies.

UOM

20µl 100µl 200µl 1ml 10ml

SPECIFITY

The antibody is a rabbit polyclonal antibody raised against SIRT1. It has been selected for its ability to recognize SIRT1 in immunohistochemical staining and western blotting.

USAGE

Western blotting: 0.5-2µg/mL;
Immunohistochemistry: 5-20µg/mL;
Immunocytochemistry: 5-20µg/mL;
Optimal working dilutions must be determined by end user.

STORAGE

Store at 4°C for frequent use. Stored at -20°C in a manual defrost freezer for two year without detectable loss of activity. Avoid repeated freeze-thaw cycles.

STABILITY

The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

Magazine

Citations

PLoS One.

SIRT1 Gene Polymorphisms Affect the Protein Expression in Cardiovascular Diseases Plos: Source

PLOS ONE

A Novel Role for SIRT-1 in L-Arginine Protection against STZ Induced Myocardial Fibrosis in Rats Pubmed:25501750

Journal of Alzheimer's Disease

Serum miR-206 and miR-132 as Potential Circulating Biomarkers for Mild Cognitive Impairment Pubmed:25589731

Respirology

Increases in peripheral SIRT1: A new biological characteristic of asthma PubMed: 26040995

PLOS ONE

A Remarkable Age-Related Increase in SIRT1 Protein Expression against Oxidative Stress in Elderly: PubMed: 25785999

Endocrine

Changes of serum Mir-217 and the correlation with the severity in type 2 diabetes patients with different stages of diabetic kidney disease. pubmed:27522360

Naunyn Schmiedebergs Arch Pharmacol

The potential curative effect of rebamipide in hepatic ischemia/reperfusion injury pubmed:28361247

International journal of cardiology

A sirtuin 1/MMP2 prognostic index for myocardial infarction in patients with advanced coronary artery disease pubmed:28043667

International Journal of Cardiology

Serum concentrations and gene expression of sirtuin 1 in healthy and slightly overweight subjects after caloric restriction or resveratrol supplementation: A randomized trial pubmed:28029409

Hepatology International

Association of SIRT1 gene polymorphism and its expression for the risk of alcoholic fatty liver disease in the Han population pubmed:29189974

Toxicology and Applied Pharmacology

Sildenafil protects against bile duct ligation induced hepaticfibrosis in rats: Potential role for silent information regulator 1 (SIRT1) pubmed:28974454

Chemico-biological Interactions

Magnolol protects pancreatic β-cells against methylglyoxal-induced cellular dysfunction pubmed:28919305

Nutrients

Gene Expression of Sirtuin-1 and Endogenous Secretory Receptor for Advanced Glycation End Products in Healthy and Slightly Overweight Subjects after … Pubmed:30037068

Experimental Gerontology

Specific alterations in the circulating levels of the SIRT1, TLR4, and IL7 proteins in patients with dementia Pubmed:30071285

Kidney and Blood Pressure Research

The Kidney Specific Protein myo-Inositol Oxygenase, a Potential Biomarker for Diabetic Nephropathy Pubmed: 30504713

Journal of International Medical Research

Serum and follicular fluid levels of sirtuin 1, sirtuin 6, and resveratrol in women undergoing fertilization: an observational, clinical study Pubmed: 30556451

BioMed Research International

Centella asiatica Prevents Increase of Hippocampal Tumor Necrosis Factor-Independently of Its Effect on Brain-Derived Neurotrophic Factor in Rat Model of Chronic …

学位论文

Influência do tratamento da doença periodontal na sirtuína 1 e na lectina ligadora de manose em indivíduos com doença arterial coronária

Journal of Physics D: Applied Physics

Premature Myocardial Infarction: Genetic Variations in SIRT1 Affect Disease Susceptibility

Journal of Geriatric Oncology

Serum biomarkers for predicting overall survival and early mortality in older patients with metastatic solid tumors Pubmed: 30952517

Biomed Research International

Prevents Increase of Hippocampal Tumor Necrosis Factor-α Independently of Its Effect on Brain-Derived Neurotrophic Factor in Rat Model of … Pubmed: 30956976

Journal of Diabetes and its Complications

Vasohibin-1 in T2DM with different UACR

Clinical Interventions in Aging

The Serum Concentration of Anti-Aging Proteins, Sirtuin1 and αKlotho in Patients with End-Stage Kidney Disease on Maintenance Hemodialysis Pubmed: 32214805

Compr Psychiatry

Crocin alleviates schizophrenia-like symptoms in rats by upregulating silent information regulator-1 and brain derived neurotrophic factor Pubmed: 33045669

Сибирский федеральный университет

Влияние гречневой крупы на сиртуиновую активность у подопытных животных в эксперименте

Journal of Cereal Science

Dietary buckwheat enhances sirtuin1 without calorie restriction

Clin Interv Aging

Molecular Changes in Circulating microRNAs' Expression and Oxidative Stress in Adults with Mild Cognitive Impairment: A Biochemical and Molecular Study 33447019

Antioxidants

The Effect of Repeated Whole-Body Cryotherapy on Sirt1 and Sirt3 Concentrations and Oxidative Status in Older and Young Men Performing Different Levels of?¡­ 33396247

Int Urol Nephrol

Evaluation of sirtuin 1 (SIRT1) levels in autosomal dominant polycystic kidney disease 33864594

Neurochem Int

Dimethyl fumarate abridged tauo-/amyloidopathy in a D-Galactose/ovariectomy-induced Alzheimer's-like disease: Modulation of AMPK/SIRT-1, AKT/CREB/BDNF, AKT ¡­ 34052296

Toxicol Appl Pharmacol

Prasugrel anti-ischemic effect in rats: Modulation of hippocampal SUMO2/3-IкBα/Ubc9 and SIRT-1/miR-22 trajectories 34174262

Food Chem

Buckwheat-enriched diet alleviates bisphenol A mediated oxidative stress via modulation of sirtuin 1 and antioxidant status in experimental rats 34763933

Life Sci

Novel mechanistic insights towards the repositioning of alogliptin in Parkinson's disease 34774622

Int J Mol Sci

Intralesional Infiltrations of Arteriosclerotic Tissue Cells-Free Filtrate Reproduce Vascular Pathology in Healthy Recipient Rats Pubmed:35163435

J Clin Med

Effects of Coffee on Sirtuin-1, Homocysteine, and Cholesterol of Healthy Adults: Does the Coffee Powder Matter? Pubmed:35683374

Cell & Bioscience

OGT Protects Skeletal Muscle From Damage Through SIRT1 O-GlcNAcylation During Cold Stress


Catalog No.

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Applications (RESEARCH USE ONLY!)

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Enzyme-linked immunosorbent assay for Antigen Detection.

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Magnetic Luminex Assay for Antigen Detection.

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ELISA; CLIA; ELISPOT; Luminex; Immunochromatography and other Immunoassays.

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ELISA Kit DIY Materials for Sirtuin 1 (SIRT1)

Main materials for "Do It (ELISA Kit) Yourself".

 

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