PRAK Polyclonal Antibody

The protein encoded by MAPKAPK5 (mitogen-activated protein kinase-activated protein kinase 5) is a tumor suppressor and member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. The encoded protein is found in the nucleus but translocates to the cytoplasm upon phosphorylation and activation. This kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. Two alternately spliced transcript variants of MAPKAPK5 encoding distinct isoforms have been reported.

The PRAK Polyclonal Antibody is a highly specific and reliable tool designed for the detection and analysis of the p38-regulated/activated protein kinase (PRAK) in various biological samples. This antibody is produced using state-of-the-art technology and rigorous quality control measures to ensure optimal performance and reproducibility.

The PRAK Polyclonal Antibody exhibits exceptional sensitivity and specificity, enabling accurate and precise quantification of PRAK expression levels. It has been extensively validated in a wide range of applications, including Western blotting, immunohistochemistry, and immunofluorescence.

With its superior affinity and selectivity, this antibody offers researchers a valuable tool for investigating the role of PRAK in cellular signaling pathways and its involvement in various physiological and pathological processes. Its versatility allows for the examination of PRAK expression and localization in different cell types and tissues, facilitating comprehensive studies in diverse research areas.

The PRAK Polyclonal Antibody is supplied as a ready-to-use solution, ensuring convenience and ease of use. Its high stability and long shelf life guarantee consistent and reliable results over time. Furthermore, it is compatible with a variety of experimental conditions and can be used in combination with other antibodies or detection methods to enhance experimental flexibility and accuracy.

In summary, the PRAK Polyclonal Antibody is a premium research tool that offers exceptional performance, reliability, and versatility. Its high specificity and sensitivity make it an indispensable asset for scientists and researchers aiming to unravel the intricate mechanisms underlying PRAK-mediated cellular processes.