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ELK Biotechnology
SKU(재고 관리 코드):ES11058
PTPRM Rabbit Polyclonal Antibody
PTPRM Rabbit Polyclonal Antibody
PTPRM Rabbit Polyclonal Antibody
Overview
| Product name: | PTPRM rabbit pAb |
| Applications: | WB;ELISA |
| Recommended Dilutions: | WB 1:500-2000 ELISA 1:5000-20000 |
| Immunogen: | Synthesized peptide derived from part region of human protein. AA range 21-61 |
| Storage: | Rabbit |
| Storage: | -20°C/1 year |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Concentration: | 1 mg/ml |
| Observed Band: | 159kD |
| GeneID（Human）: | 5797 |
| Human Swiss-Prot No: | P28827 |
| Cellular localization: | Cell membrane ; Single-pass type I membrane protein. Localizes in regions of cell-cell contact. . |
| Background: | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP has been shown to mediate cell-cell aggregation through the interaction with another molecule of this PTP on an adjacent cell. This PTP can interact with scaffolding protein RACK1/GNB2L1, which may be necessary for the downstream signaling in response to cell-cell adhesion. Alternative splicing results in multiple transcrip |
| Species Reactivity: | Human;Mouse |
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