Anhidrotic ectodermal dysplasia is an X-linked recessive disorder which affects ectodermal structures. Ectodysplasin-A, the protein encoded by the EDA gene, is a member of the tumor necrosis factor ligand superfamily that forms a collagen triple helix, suggesting functions in signal transduction and cell adhesion. Wnt signaling controls EDA gene expression, but Ectodysplasin-A does not feedback on the Wnt pathway.
